Ryan is a Ph.D. candidate studying translational human genomics in the Bioinformatics and Integrative Genomics program at Harvard Medical School. He is supported by an award from the Graduate Research Fellowship Program (GRFP) through the National Science Foundation (NSF).

Click here to read more about Ryan's research interests and publications, or to see his CV.

Structure Meets Function (Blog)

Strength in numbers: genetic sequencing of large populations is shaping the future of medicine

Recently, I wrote a short peice for a great local science news & media outlet, Science In The News (SITN), to explain how population-scale genetic sequencing is driving major advances in precision medicine.

The article is targeted primarily for the lay public (i.e. non-specialists), so it's mostly jargon-free. It gets even better for those among us who are more visually inclined learners: a fellow PhD student at HMS, Brad Wierbowski, put together some great graphical figures to explain the core concepts (thanks Brad!).

While not a...

Read more about Strength in numbers: genetic sequencing of large populations is shaping the future of medicine


  • ryanlcollins13
    ryanlcollins13 /my first Twitter explainer Was awesome to work on this over last ~3 years. Great group of collaborators! Looking forward to much more WGS soon. ~Fin~ 15/15
  • ryanlcollins13
    ryanlcollins13 In summary: WGS is an exciting/tantalizing data type that is on track to revolutionize aspects of human genetics. That said... please, please treat significant noncoding associations from small studies with skepticism until multiply replicated in larger cohorts. 14/15
  • ryanlcollins13
    ryanlcollins13 Further, we find a couple hundred de novo & mosaic SV in children one would want to consider in WGS studies. Molecular confirmation rate > 97% Some are even likely relevant to autism, like a de novo balanced translocation of GRIN2B or a de novo 4-exon CHD2 deletion. 13/15 t.co/sZhhpKPPgp
  • ryanlcollins13
    ryanlcollins13 The _vast_ majority of SV are small & rare. Analyses restricted to large or common SV get the tip of a much bigger iceberg (but still better than nothing!) 12/15 t.co/AtGeCo2TPB