Welcome
Ryan is a Ph.D candidate in the Bioinformatics and Integrative Genomics (BIG) program at Harvard Medical School, and is a member of the Talkowski lab at Massachusetts General Hospital and The Broad Institute. He is supported by an award from the Graduate Research Fellowship Program (GRFP) through the National Science Foundation (NSF).
His research focuses on the structure of the human genome, and how changes to genome structure contribute to human diversity and disease. He has led and contributed to numerous large-scale sequencing studies, such as the Genome Aggregation Database (gnomAD), one of the most widely adopted reference catalogs of human genetic variation in the world.
Click here to read more about Ryan's research interests and publications, or to see his CV.
Structure Meets Function (Blog)
@ryanlcollins13
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Our work on germline hypermutation and the potential genetic and chemotherapeutic influences on this phenomenon from the @mehurles group is now published! t.co/9QKrH5a5MM Quick summary below 👇
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Do you culture cells this fast? Join us in the @TalkowskiLab to model human neurodevelopmental disorders! Various open positions. DM or t.co/u0YIQ9wkWa for more info. t.co/8EkGbA7Nl8
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New track! The gnomAD Genomes Mutation Constraint track on the human GRCh38/hg38 genome. This track uses the latest gnomAD data to calculate selection pressure, using relative frequency of variation in 1 kilobase windows across the genome. Try it here: t.co/YWgDZbf8Tk t.co/EZ2z3wDIXx
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I'm hiring postdocs to join my team at @CGM_MGH & Broad! We study patterns of rare variation in large genomic datasets (like gnomAD), and leverage those into insights about genetic risk for disease. If you are interested, please reach out or apply here: t.co/2MOkF3sij8
