Welcome
Ryan is a Ph.D candidate in the Bioinformatics and Integrative Genomics (BIG) program at Harvard Medical School, and is a member of the Talkowski lab at Massachusetts General Hospital and The Broad Institute. He is supported by an award from the Graduate Research Fellowship Program (GRFP) through the National Science Foundation (NSF).
His research focuses on the structure of the human genome, and how changes to genome structure contribute to human diversity and disease. He has led and contributed to numerous large-scale sequencing studies, such as the Genome Aggregation Database (gnomAD), one of the most widely adopted reference catalogs of human genetic variation in the world.
Click here to read more about Ryan's research interests and publications, or to see his CV.
Structure Meets Function (Blog)
@ryanlcollins13
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Pedantic clarification on the CHM13 genome. It *is* diploid (46,XX karyotype), just much less heterozygous than a typical human cell. On the order of 1 heterozygous variant per million bases vs. 1 per thousand. t.co/pMj2r4rqEg
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We're in the market for postdocs (plural!) to work on a variety of funded projects. Interested in Mendelian genetics? Complex traits? Noncoding variants? Genetic modifiers of syndromic phenotypes? We've got you covered. Apply here: t.co/3ENAKOoRiy
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Really enjoying reading Sean Eddy's "Antedisciplinary Science" piece all these years later @PLOSCompBiol t.co/AcRAEgzZgJ t.co/5l8lpkDV9n
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Excited to share a preprint about our project in which we aim to computationally reconstruct the cellular trajectories of mammalian embryogenesis, which started in my lab rotation at the beginning of my PhD. Many thanks to @JShendure and my rotation mentor @junyue_cao !! t.co/nZl9DgeSxf
