(Preface: For details on Ryan’s research and professional activities, see his CV, list of publications, or research summary.)

Ryan defending his Ph.D. thesis

Ryan was born in southern California and raised in central New Hampshire, where he subsequently attended Dartmouth College, receiving his A.B. in Genetics in 2013. While at Dartmouth, Ryan primarily trained in statistical human genetics under Dr. Jason Moore, also gaining exposure to classical molecular genetics in Dr. Thomas Jack’s Arabidopsis lab.


Upon graduating from Dartmouth, Ryan joined the lab of Dr. Michael Talkowski as a bioinformatics analyst at Massachusetts General Hospital (MGH) and the Broad Institute of M.I.T. and Harvard. In the Talkowski Lab, Ryan primarily focused on characterizing structural variation in pediatric developmental disorders like autism and methods development for whole-genome sequencing (WGS) analysis. In addition to his two primary research focuses, Ryan also led bioinformatics analyses for projects including whole-exome sequencing in congenital anomalies, targeted capture sequencing in genetically engineered human stem cells, and fine-mapping disease haplotypes in rare neuromuscular disorders, as well as several non-human disease modeling projects through the MGH Genomics and Technology Core.


Broad CMG Course Teaching Picture


In the fall of 2016, Ryan joined the Ph.D. Program in Bioinformatics and Integrative Genomics at Harvard Medical School. Ryan continued to train in statistical and computational genomics during his Ph.D., where he led and contributed to numerous large-scale sequencing studies, such as the Genome Aggregation Database (gnomAD), one of the most widely adopted reference catalogs of human genetic variation. Ryan defended his Ph.D. in August 2022 and has recently joined the labs of Drs. Eli Van Allen, Sasha Gusev, and Kevin Haigis at Dana-Farber Cancer Institute to study the germline genetic contributions of cancer predisposition.


Ryan lives in Brookline with his wife, Sam, their daughter, Summer, and their dog. Outside of the lab, he enjoys running, skiing, hiking, listening to electronic music, and supporting New England sports teams.