Broad CMG Course Teaching Picture

Ryan was born in southern California and raised in central New Hampshire, where he subsequently attended Dartmouth College, receiving his A.B. in 2013 from the Department of Biological Sciences. While at Dartmouth, Ryan primarily trained in statistical genetics under Dr. Jason Moore, but also also gained exposure to classical molecular genetics as an intern in the lab of Dr. Thomas Jack and assisted in running the introductory undergraduate Genetics lab course

Upon graduating from Dartmouth, Ryan joined the lab of Dr. Michael Talkowski at Massachusetts General Hospital (MGH), the Broad Institute of M.I.T. and Harvard, and Harvard Medical School. In the Talkowski Lab, Ryan largely focused on characterizing structural variation in pediatric, neurological, and developmental disorders like autism and methods development for whole-genome sequencing (WGS) analysis. Ryan's research emphasized forms of genetic variation largely cryptic to previous studies, such as large inversions and complex genome rearrangements. In addition to his primary research foci, Ryan also contributed to projects including whole-exome sequencing in congenital anomalies, targeted capture sequencing in genetically engineered human stem cells, and fine-mapping disease haplotypes in rare neuromuscular disorders, as well as several non-human disease modeling projects through the MGH Genomics and Technology Core

Currently, Ryan is pursuing a PhD in genomics through the BIG PhD Program at Harvard Medical School. He decided to stay on with the Talkowski laboratory for his dissertation, where he is extending his previous research on genome structural variation in human disease towards the population genetics, functional effects, and disease relevance of genomic rearrangements through integrated genome, transcriptome, and epigenome studies. As part of this work, he has led the analyses of structural variation in the Genome Aggregation Database, gnomAD

For details on Ryan’s research and professional activities, see his CV, list of publications, or research summary.

Ryan in the Talkowski Lab

Personal interests: Ryan's favorite season is winter, and he is an avid outdoorsman. He enjoys freestyle skiing, but entertains himself during the other six New England months by running, wakeboarding, hiking, waterskiing, pick-up ice hockey, and various other recreation. Ryan enjoys spending time with his fiancee, friends, and colleagues, and has a decade-long interest in music production and DJing.