Our collaboration with Sam Schilit, Cynthia Morton, and the rest of the DGAP team on a case of congenital hearing loss with a de novo balanced translocation, dubbed DGAP242, was published this week in European Journal of Human Genetics. The article can be viewed here. Congrats to...
MLLthingsDNA1/5 Here's work done by myself and others showing that CRISPR-Cas9 cuts lead to abnormal nuclear structures, especially micronuclei. These micronuclei in turn function as 'mutator organelles' causing chromosome shattering and restitching (chromothripsis) telomeric of the cut site t.co/ZWX7TlUEng
RyanLCollins13Want dozens of CRISPR-edited cell lines but don't want to make them one at a time?
Check out this new method from Xander in the @TalkowskiLab to create isogenic human iPS models with edited genomes all in one shot:
Congrats, Xander & team!