Ryan L. Collins, A.B.
NSF Graduate Research Fellow & Ph.D. Candidate
Program in Bioinformatics and Integrative Genomics
Harvard Medical School, Boston, MA
Contact
rlcollins [at] g.harvard.edu
Blog posts by month
- March 2019 (1)
- June 2017 (1)
- November 2016 (1)
- July 2016 (1)
- April 2016 (1)
@ryanlcollins13
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1/5 Here's work done by myself and others showing that CRISPR-Cas9 cuts lead to abnormal nuclear structures, especially micronuclei. These micronuclei in turn function as 'mutator organelles' causing chromosome shattering and restitching (chromothripsis) telomeric of the cut site t.co/ZWX7TlUEng
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Here, Xander & Nick cleverly combined: 1. piggyBac delivery of Cas9 & guide RNA libraries & 2. FACS & multiplexed high-throughput clone genotyping with molecular inversion probes (MIPS) End result: highly parallel scarless genome integration & editing in isogenic clones! t.co/sL5mQM2gy0
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Want dozens of CRISPR-edited cell lines but don't want to make them one at a time? Check out this new method from Xander in the @TalkowskiLab to create isogenic human iPS models with edited genomes all in one shot: t.co/4QxuDE9I0h Congrats, Xander & team!
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An article worth reading about DR🧐 t.co/2rN9lItVq4
