Recently, I wrote a short peice for a great local science news & media outlet, Science In The News (SITN), to explain how population-scale genetic sequencing is driving major advances in precision medicine.
The article is targeted primarily for the lay public (i.e. non-specialists), so it's mostly jargon-free. It gets even better for those among us who are more visually inclined learners: a fellow PhD student at HMS, Brad Wierbowski, put together some great graphical figures to explain the core concepts (thanks Brad!).
RyanLCollins13@kaptenkvast Great catch—I agree that coverage could definitely be a factor here, especially if it resulted in differential sensitivity across the frequency range.
I still need to read the methods in detail so perhaps there are additional technical explanations for this observation