Recently, I wrote a short peice for a great local science news & media outlet, Science In The News (SITN), to explain how population-scale genetic sequencing is driving major advances in precision medicine.
The article is targeted primarily for the lay public (i.e. non-specialists), so it's mostly jargon-free. It gets even better for those among us who are more visually inclined learners: a fellow PhD student at HMS, Brad Wierbowski, put together some great graphical figures to explain the core concepts (thanks Brad!).
MLLthingsDNA1/5 Here's work done by myself and others showing that CRISPR-Cas9 cuts lead to abnormal nuclear structures, especially micronuclei. These micronuclei in turn function as 'mutator organelles' causing chromosome shattering and restitching (chromothripsis) telomeric of the cut site t.co/ZWX7TlUEng
RyanLCollins13Want dozens of CRISPR-edited cell lines but don't want to make them one at a time?
Check out this new method from Xander in the @TalkowskiLab to create isogenic human iPS models with edited genomes all in one shot:
Congrats, Xander & team!