Last week, we released the initial structural variant (SV) callset for the Genome Aggregation Database (gnomAD), which included nearly a half-million distinct SVs discovered across ~15 thousand human whole-genome sequences.
MLLthingsDNA1/5 Here's work done by myself and others showing that CRISPR-Cas9 cuts lead to abnormal nuclear structures, especially micronuclei. These micronuclei in turn function as 'mutator organelles' causing chromosome shattering and restitching (chromothripsis) telomeric of the cut site t.co/ZWX7TlUEng
RyanLCollins13Want dozens of CRISPR-edited cell lines but don't want to make them one at a time?
Check out this new method from Xander in the @TalkowskiLab to create isogenic human iPS models with edited genomes all in one shot:
Congrats, Xander & team!