@article {689769,
	title = {Case-control study of vitamin D status and adult multidrug-resistant pulmonary tuberculosis in Mumbai, India},
	journal = {International Journal of Tuberculosis and Lung Disease},
	volume = {26},
	number = {9},
	year = {2022},
	month = {1 Sep, 2022},
	pages = {826-834},
	abstract = {
	BACKGROUND:\&nbsp;India has the highest prevalence of multidrug-resistant TB (MDR-TB) globally. Vitamin D deficiency is potentially an important risk factor for MDR-TB.\&nbsp;METHODS:\&nbsp;We conducted a case-control study of 90 newly diagnosed adult MDR-TB cases, 180 household controls and 82 non-household controls in Mumbai, India. Serum 25-hydroxyvitamin D (25(OH)D), anthropometry, clinical status and history, dietary data and sociodemographic data were collected from each participant. Interferon-gamma release assay (IGRA) was also performed in controls to assess latent TB. Multivariable regression was performed to estimate associations between 25(OH)D vs. case status and IGRA positivity.\&nbsp;RESULTS:\&nbsp;Mean participant age was 33.8 {\textpm} 12.0 years; 72.8\% had 25(OH)D \&lt;20 ng/ml. Mean 25(OH)D was significantly (P\&nbsp;\&lt; 0.05) lower in cases (12.5 {\textpm} 7.9) than both household (17.5 {\textpm} 11.2) and non-household controls (16.4 {\textpm} 9.1). In multivariable models, 25(OH)D concentration was inversely associated with MDR-TB case status among cases and household controls (OR 0.95 per 1 ng/ml, 95\% CI 0.92-0.99;\&nbsp;P\&nbsp;= 0.015), and among cases and non-household controls (OR 0.94 per 1 ng/ml, 95\% CI 0.89-1.00;\&nbsp;P\&nbsp;= 0.033); 53.6\% of controls were IGRA-positive. 25(OH)D status was not associated with IGRA positivity.\&nbsp;CONCLUSION:\&nbsp;Vitamin D status was independently associated with MDR-TB case status. Research should evaluate the effectiveness of vitamin D supplementation in prevention and adjunctive treatment of MDR-TB.

},
	url = {https://www.ingentaconnect.com/contentone/iuatld/ijtld/2022/00000026/00000009/art00005},
	author = {Anupam Shukla and Sabri Bromage and Yatin Dholakia and Elena C. Hemler and Prachi Dev and Laxmi Govekar and Pranita Tipre and Daksha Shah and Salmaan A. Keshavjee and Molin Wang and Nerges Mistry and Wafaie W. Fawzi}
}
