Publications

2020
Sandra Romero Pinto, A Height, K Clayton, Jennifer R, R Williamson, K Hancock, and Daniel Polley. 3/2020. “Cellular and widefield imaging of sound frequency organization in primary and higher order fields of the mouse auditory cortex.” Cerebral Cortex, 30, 3, Pp. 1603-1622https://academic.oup.com/cercor/article/30/3/1603/5610045. Publisher's Version romero_pinto_cerebral_cortex_2020.pdf
P. Aravindakshan, S Romero Pinto, R Lewis, W Goedicke, and D Polley. 2020. “Data-driven segmentation of audiometric phenotypes across a large clinical cohort.” Scientific Reports, 10, Pp. 6704. aravind_scientific_reports.pdf
V Gaillet, A Cutrone, F Artoni, P Vagni, A Mega Pratiw, S Romero Pinto, and D Ghezzi. 2020. “Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve.” Nature Biomedical Engineering, 4, Pp. 181–194. Publisher's Version gaillet_nat_biom.pdf
2019
C.A Nist-Lund, B Pan, A Patterson, Y Asai, C Tianwen, W. Zhou, H. Zhu, S Romero Pinto, J Resnik, D Polley, G Géléoc, and J Holt. 2019. “Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.” Nature Communications, 10 , 236. Publisher's Version nist-lund_nat_com.pdf
1979
K Bry, LC Andersson, T Kuusi, and PK Kinnunen. 1979. “Monoacylglycerol hydrolase in human platelets.” Biochim Biophys Acta, 575, 1, Pp. 121-7.Abstract
In the present paper we show for the first time monoacylglycerol hydrolase in human platelets. No monoacylglycerol hydrolase activity could be demonstrated in the other blood cells. The monoacylglycerol hydrolase of platelets could not be released from the cells by heparin, thus the enzyme is distinct from the postheparin plasma lipases. The enzyme could be solubilized by a non-ionic detergent, Triton X-100. The solubilized monoacylglycerol hydrolase from platelets was optimally active at pH between 7 and 8 and at ionic strength corresponding to [NaCl] between 0.1 and 0.3 M. The optimal assay temperature was 37 degrees C. The enzyme activity was sensitive to HgCl2 but not to NaF. Accordingly, it was stabilized by 2-mercaptoethanol.
1976
CR Westwick. 1976. “Item analysis.” J Nurs Educ, 15, 1, Pp. 27-32.
N Gruener. 1976. “Ontogenetic development of NADH-dependent methemoglobin reductase in erythrocytes of man and rat.” J Toxicol Environ Health, 1, 5, Pp. 787-91.Abstract
Ontogenetic development of NADH-dependent methemoglobin reductase was followed in humans and rats. The human kinetic profile differs from that in the rat. The low level of methemoglobin reductase in human infants at birth and for the first months of life may provide a partial explanation of the particular susceptibility to methemoglobinemic agents of this age group.
J Roberts, GJ Kelliher, and CM Lathers. 1976. “Role of adrenergic influences in digitalis-induced ventricular arrhythmia.” Life Sci, 18, 7, Pp. 665-77.
1975
JM Jallon, Y Risler, and M Iwatsubo. 1975. “Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.” Biochem Biophys Res Commun, 67, 4, Pp. 1527-36.
YM Berkmen and A Lande. 1975. “Chest roentgenography as a window to the diagnosis of Takayasu's arteritis.” Am J Roentgenol Radium Ther Nucl Med, 125, 4, Pp. 842-6.Abstract
The chest roentgenographic findings in Takayasu's arteritis include widening of the ascending aorta, contour irregularities of the descending aorta, arotic calcifications, pulmonary arterial changes, rib notching, and hilar lymphadenopathy. The single most important diagnostic sign is a segmental calcification outlining a localized or diffuse narrowing of the aorta. The other signs may be suspicious or suggestive, but the diagnostic accuracy increases when several findings are present simultaneously.
KS Bose and RH Sarma. 1975. “Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution.” Biochem Biophys Res Commun, 66, 4, Pp. 1173-9.
M Ardenne and PG Reitnauer. 1975. “[Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a.” Arzneimittelforschung, 25, 9, Pp. 1369-79.Abstract
A report is given on the recent discovery of outstanding immunological properties in BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40 percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. Under otherwise unchanged conditions the reference substance ifosfamide (IF) -- a further development of cyclophosphamide -- applied without hyperglycemia in its most efficient dosage of 47 percent LD50 (150 mg kg) brought about a recovery rate of 25 percent at a lethality of 18 percent. (Contrary to BA 1, 250-min hyperglycemia caused no further improvement of the recovery rate.) However this comparison is characterized by the fact that both substances exhibit two quite different (complementary) mechanisms of action. Leucocyte counts made after application of the said cancerostatics and dosages have shown a pronounced stimulation with BA 1 and with ifosfamide, the known suppression in the post-therapeutic interval usually found with standard cancerostatics. In combination with the cited plaque test for BA 1, blood pictures then allow conclusions on the immunity status. Since IF can be taken as one of the most efficient cancerostatics--there is no other chemotherapeutic known up to now that has a more significant effect on the DS carcinosarcoma in rats -- these findings are of special importance. Finally, the total amount of leucocytes and lymphocytes as well as their time behaviour was determined from the blood picture of tumour-free rats after i.v. application of BA 1. The thus obtained numerical values clearly show that further research work on the prophylactic use of this substance seems to be necessary and very promising.
A Schmoldt, HF Benthe, and G Haberland. 1975. “Digitoxin metabolism by rat liver microsomes.” Biochem Pharmacol, 24, 17, Pp. 1639-41.
AB Makar, KE McMartin, M Palese, and TR Tephly. 1975. “Formate assay in body fluids: application in methanol poisoning.” Biochem Med, 13, 2, Pp. 117-26.
MM Ris, RA Deitrich, and JP Von Wartburg. 1975. “Inhibition of aldehyde reductase isoenzymes in human and rat brain.” Biochem Pharmacol, 24, 20, Pp. 1865-9.