%0 Journal Article %J Cerebral Cortex %D 2020 %T Cellular and widefield imaging of sound frequency organization in primary and higher order fields of the mouse auditory cortex %A Romero Pinto, Sandra %A Height, A %A Clayton, K %A Jennifer R %A Williamson, R %A K Hancock %A Polley, Daniel %B Cerebral Cortex %V 30 %P 1603-1622https://academic.oup.com/cercor/article/30/3/1603/5610045 %G eng %U https://academic.oup.com/cercor/article/30/3/1603/5610045 %N 3 %0 Journal Article %J Scientific Reports %D 2020 %T Data-driven segmentation of audiometric phenotypes across a large clinical cohort %A Aravindakshan,P. %A Romero Pinto, S %A Lewis, R %A W Goedicke %A D Polley %B Scientific Reports %V 10 %P 6704 %G eng %0 Journal Article %J Nature Biomedical Engineering %D 2020 %T Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve %A Gaillet, V %A Cutrone, A %A Artoni,F %A Vagni,P %A Mega Pratiw, A %A Romero Pinto, S %A Ghezzi, D %B Nature Biomedical Engineering %V 4 %P 181–194 %G eng %U https://www.nature.com/articles/s41551-019-0446-8#citeas %0 Journal Article %J Nature Communications %D 2019 %T Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders %A Nist-Lund, C.A %A B Pan %A A Patterson %A Y Asai %A Tianwen, C %A Zhou, W. %A Zhu, H. %A Romero Pinto, S %A J Resnik %A D Polley %A Géléoc, G %A Holt, J %B Nature Communications %V 10 %G eng %U https://www.nature.com/articles/s41467-018-08264-w %N 236 %0 Journal Article %J Biochim Biophys Acta %D 1979 %T Monoacylglycerol hydrolase in human platelets %A Bry, K %A Andersson, L C %A Kuusi, T %A Kinnunen, P K %K Apolipoproteins %K Blood Platelets %K Carboxylic Ester Hydrolases %K Heparin %K Humans %K Hydrogen-Ion Concentration %K Mercaptoethanol %K Mercury %K Monoacylglycerol Lipases %K Osmolar Concentration %K Polyethylene Glycols %K Sodium Fluoride %K Solubility %K Temperature %X In the present paper we show for the first time monoacylglycerol hydrolase in human platelets. No monoacylglycerol hydrolase activity could be demonstrated in the other blood cells. The monoacylglycerol hydrolase of platelets could not be released from the cells by heparin, thus the enzyme is distinct from the postheparin plasma lipases. The enzyme could be solubilized by a non-ionic detergent, Triton X-100. The solubilized monoacylglycerol hydrolase from platelets was optimally active at pH between 7 and 8 and at ionic strength corresponding to [NaCl] between 0.1 and 0.3 M. The optimal assay temperature was 37 degrees C. The enzyme activity was sensitive to HgCl2 but not to NaF. Accordingly, it was stabilized by 2-mercaptoethanol. %B Biochim Biophys Acta %V 575 %P 121-7 %8 1979 Oct 26 %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/41586?dopt=Abstract %R 10.1016/0005-2760(79)90137-1 %0 Journal Article %J J Nurs Educ %D 1976 %T Item analysis %A Westwick, C R %K Achievement %K Discrimination, Psychological %K Education, Nursing %K Educational Measurement %K Evaluation Studies as Topic %K Humans %B J Nurs Educ %V 15 %P 27-32 %8 1976 Jan %G eng %N 1 %1 http://www.ncbi.nlm.nih.gov/pubmed/1476?dopt=Abstract %0 Journal Article %J J Toxicol Environ Health %D 1976 %T Ontogenetic development of NADH-dependent methemoglobin reductase in erythrocytes of man and rat %A Gruener, N %K Adult %K Aging %K Animals %K Cytochrome-B(5) Reductase %K Erythrocytes %K Female %K Fetal Blood %K Fetus %K Humans %K Infant %K Infant, Newborn %K NADH, NADPH Oxidoreductases %K NADP %K Pregnancy %K Rats %K Species Specificity %X Ontogenetic development of NADH-dependent methemoglobin reductase was followed in humans and rats. The human kinetic profile differs from that in the rat. The low level of methemoglobin reductase in human infants at birth and for the first months of life may provide a partial explanation of the particular susceptibility to methemoglobinemic agents of this age group. %B J Toxicol Environ Health %V 1 %P 787-91 %8 1976 May %G eng %N 5 %1 http://www.ncbi.nlm.nih.gov/pubmed/5611?dopt=Abstract %R 10.1080/15287397609529377 %0 Journal Article %J Life Sci %D 1976 %T Role of adrenergic influences in digitalis-induced ventricular arrhythmia %A Roberts, J %A Kelliher, G J %A Lathers, C M %K Adrenal Medulla %K Adrenergic beta-Antagonists %K Animals %K Anti-Arrhythmia Agents %K Arrhythmias, Cardiac %K Blood Pressure %K Catecholamines %K Digitalis Glycosides %K Drug Synergism %K Evoked Potentials %K Heart %K Heart Ventricles %K Histamine %K Motor Neurons %K Ouabain %K Reserpine %K Sympathetic Nervous System %B Life Sci %V 18 %P 665-77 %8 1976 Apr 01 %G eng %N 7 %1 http://www.ncbi.nlm.nih.gov/pubmed/4687?dopt=Abstract %R 10.1016/0024-3205(76)90177-6 %0 Journal Article %J Biochem Biophys Res Commun %D 1975 %T Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH %A Jallon, J M %A Risler, Y %A Iwatsubo, M %K Animals %K Cattle %K Glutamate Dehydrogenase %K Ketoglutaric Acids %K Kinetics %K Liver %K NADP %K Oxidation-Reduction %K Spectrometry, Fluorescence %K Spectrophotometry, Ultraviolet %B Biochem Biophys Res Commun %V 67 %P 1527-36 %8 1975 Dec 15 %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/1038?dopt=Abstract %R 10.1016/0006-291x(75)90200-4 %0 Journal Article %J Am J Roentgenol Radium Ther Nucl Med %D 1975 %T Chest roentgenography as a window to the diagnosis of Takayasu's arteritis %A Berkmen, Y M %A Lande, A %K Adolescent %K Adult %K Aorta %K Aortic Arch Syndromes %K Arteritis %K Calcinosis %K Female %K Humans %K Hypertension, Pulmonary %K Lymphatic Diseases %K Middle Aged %K Radiography %K Ribs %K Takayasu Arteritis %K United States %X The chest roentgenographic findings in Takayasu's arteritis include widening of the ascending aorta, contour irregularities of the descending aorta, arotic calcifications, pulmonary arterial changes, rib notching, and hilar lymphadenopathy. The single most important diagnostic sign is a segmental calcification outlining a localized or diffuse narrowing of the aorta. The other signs may be suspicious or suggestive, but the diagnostic accuracy increases when several findings are present simultaneously. %B Am J Roentgenol Radium Ther Nucl Med %V 125 %P 842-6 %8 1975 Dec %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/2023?dopt=Abstract %R 10.2214/ajr.125.4.842 %0 Journal Article %J Biochem Biophys Res Commun %D 1975 %T Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution %A Bose, K S %A Sarma, R H %K Fourier Analysis %K Magnetic Resonance Spectroscopy %K Models, Molecular %K Molecular Conformation %K NAD %K NADP %K Structure-Activity Relationship %K Temperature %B Biochem Biophys Res Commun %V 66 %P 1173-9 %8 1975 Oct 27 %G eng %N 4 %1 http://www.ncbi.nlm.nih.gov/pubmed/2?dopt=Abstract %R 10.1016/0006-291x(75)90482-9 %0 Journal Article %J Arzneimittelforschung %D 1975 %T [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a %A Ardenne, M %A Reitnauer, P G %K Animals %K Antineoplastic Agents %K Carcinosarcoma %K Cyclophosphamide %K Drug Evaluation, Preclinical %K Drug Tolerance %K Erythrocyte Count %K Hydrogen-Ion Concentration %K Hyperglycemia %K Ifosfamide %K Immunity %K Immunosuppression Therapy %K Lethal Dose 50 %K Leukocyte Count %K Male %K Mice %K Neoplasms, Experimental %K Rats %K Stimulation, Chemical %K Time Factors %K Urea %X A report is given on the recent discovery of outstanding immunological properties in BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS carcinosarcoma bearing Wistar rats have shown that BA 1, at a dosage of only about 12 percent LD50 (150 mg kg) and negligible lethality (1.7 percent), results in a recovery rate of 40 percent without hyperglycemia and, in one test, of 80 percent with hyperglycemia. Under otherwise unchanged conditions the reference substance ifosfamide (IF) -- a further development of cyclophosphamide -- applied without hyperglycemia in its most efficient dosage of 47 percent LD50 (150 mg kg) brought about a recovery rate of 25 percent at a lethality of 18 percent. (Contrary to BA 1, 250-min hyperglycemia caused no further improvement of the recovery rate.) However this comparison is characterized by the fact that both substances exhibit two quite different (complementary) mechanisms of action. Leucocyte counts made after application of the said cancerostatics and dosages have shown a pronounced stimulation with BA 1 and with ifosfamide, the known suppression in the post-therapeutic interval usually found with standard cancerostatics. In combination with the cited plaque test for BA 1, blood pictures then allow conclusions on the immunity status. Since IF can be taken as one of the most efficient cancerostatics--there is no other chemotherapeutic known up to now that has a more significant effect on the DS carcinosarcoma in rats -- these findings are of special importance. Finally, the total amount of leucocytes and lymphocytes as well as their time behaviour was determined from the blood picture of tumour-free rats after i.v. application of BA 1. The thus obtained numerical values clearly show that further research work on the prophylactic use of this substance seems to be necessary and very promising. %B Arzneimittelforschung %V 25 %P 1369-79 %8 1975 Sep %G ger %N 9 %1 http://www.ncbi.nlm.nih.gov/pubmed/22?dopt=Abstract %0 Journal Article %J Biochem Pharmacol %D 1975 %T Digitoxin metabolism by rat liver microsomes %A Schmoldt, A %A Benthe, H F %A Haberland, G %K Animals %K Chromatography, Thin Layer %K Digitoxigenin %K Digitoxin %K Hydroxylation %K In Vitro Techniques %K Male %K Microsomes, Liver %K NADP %K Rats %K Time Factors %B Biochem Pharmacol %V 24 %P 1639-41 %8 1975 Sep 01 %G eng %N 17 %1 http://www.ncbi.nlm.nih.gov/pubmed/10?dopt=Abstract %0 Journal Article %J Biochem Med %D 1975 %T Formate assay in body fluids: application in methanol poisoning %A Makar, A B %A McMartin, K E %A Palese, M %A Tephly, T R %K Aldehyde Oxidoreductases %K Animals %K Body Fluids %K Carbon Dioxide %K Formates %K Haplorhini %K Humans %K Hydrogen-Ion Concentration %K Kinetics %K Methanol %K methods %K Pseudomonas %B Biochem Med %V 13 %P 117-26 %8 1975 Jun %G eng %N 2 %1 http://www.ncbi.nlm.nih.gov/pubmed/1?dopt=Abstract %R 10.1016/0006-2944(75)90147-7 %0 Journal Article %J Biochem Pharmacol %D 1975 %T Inhibition of aldehyde reductase isoenzymes in human and rat brain %A Ris, M M %A Deitrich, R A %A Von Wartburg, J P %K Aldehyde Oxidoreductases %K Animals %K Anticonvulsants %K Barbiturates %K Brain %K Glutethimide %K Humans %K Hydantoins %K In Vitro Techniques %K Isoenzymes %K Kinetics %K NAD %K NADP %K Rats %K Succinimides %B Biochem Pharmacol %V 24 %P 1865-9 %8 1975 Oct 15 %G eng %N 20 %1 http://www.ncbi.nlm.nih.gov/pubmed/18?dopt=Abstract %R 10.1016/0006-2952(75)90405-0