Journal Articles

  • JL Braff*, SJ Yaung*, KM Esvelt, GM Church. Characterization of Cas9-gRNA Orthologs. Cold Spring Harbor Lab Protocols (2016).

  • JL Braff*, SJ Yaung*, KM Esvelt, GM Church. Characterizing Cas9 Protospacer-Adjacent Motifs with High-Throughput Sequencing of Library Depletion Experiments. Cold Spring Harbor Lab Protocols (2016).
  • SJ Yaung, L Deng, N Li, JL Braff, GM Church, L Bry, HH Wang, GK Gerber. Improving microbial fitness in the mammalian gut using in vivo temporal functional metagenomics. Molecular Systems Biology 11:788 (2015).

  • SJ Yaung, KM Esvelt, GM Church. Complete Genome Sequences of T4-like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68. Genome Announcements 3:e01122-14 (2015).
  • SJ Yaung*, KM Esvelt*, GM Church. CRISPR/Cas9-mediated phage resistance is not impeded by the DNA modifications of phage T4. PLOS ONE 9:e98811 (2014).

  • SJ Yaung, GM Church, HH Wang. Recent Progress in Engineering Human-associated Microbiomes, Methods in Molecular Biology 1151:3-25 (2014).
  • KM Esvelt, P Mali, JL Braff, M Moosburner, SJ Yaung, GM Church. Orthogonal Cas9 Proteins for RNA-guided Gene Regulation and Editing. Nature Methods 10:1116-1121 (2013).

  • G Zhou, A Moment, S Yaung, A Cote, T Hu. Evolution and Application of an Automated Platform for the Development of Crystallization Processes. Organic Process Research & Development 17:1320-1329 (2013).
  • PB Matthews, C Jhun, S Yaung, AN Azadani, JM Guccione, L Ge, EE Tseng. Finite Element Modeling of the Pulmonary Autograft at Systemic Pressure before Remodeling. Journal of Heart Valve Disease 20:45-52 (2011).

Please see Google Scholar for links to articles.


Invited Talks

  • "Quantamerix and understanding public health challenges in rural China" at Global Health & Engineering Meetup at Boston University, Boston, Massachusetts. October 10, 2014.

  • "DNA Modifications Do Not Impede Cas9 Activity" at 114th General Meeting of the American Society for Microbiology, Boston, Massachusetts. May 20, 2014. Selected Young Investigator Oral Presenter to speak in symposium on "Genome Engineering and Control of Bacterial Physiology Mediated by Small RNAs".



  • I Garcia-Murillas, P Proszek, C Fribbens, L Yuan, H Bye, M Hubank, J Jiang, S Yaung, J Palma, S Johnston, A Ring, N Turner. "Circulating tumor DNA analysis with ultra-high sensitivity sequencing in metastatic breast cancer." Poster presented at San Antonio Breast Cancer Symposium, San Antonio, Texas. December 5-9, 2017.

  • Y Jiang, H Adams, L Yao, S Yaung, F Fuhlbrueck, S Froehler, L Fang, P Lai, J Achenbach, O Oster, O Schega, R Kruegel, J Palma, A Rosenthal. "Concordance of Genomic Alterations by Next Generation Sequencing (NGS) in Tumor Tissue versus Cell-Free DNA in Stage I-IV NSCLC." Poster presented at Association for Molecular Pathology Annual Meeting, Salt Lake City, Utah. November 16-18, 2017.

  • AF Lovejoy, A Pati, A Munoz, S Yaung, J Jin, D Klass. "In-depth Assessment Reveals Powerful Performance and Flexibility of AVENIO ctDNA Analysis Kits." Poster presented at Association for Molecular Pathology Annual Meeting, Salt Lake City, Utah. November 16-18, 2017.

  • J Jiang, H Adams, M Lange, S Siemann, M Feldkamp, S Schulze, S Froehler, S Yaung, L Yao, A Balasubramanyam, N Tikoo, HJ Achenbach, R Krügel, J Palma, A Rosenthal. "Longitudinal Mutation Monitoring in Plasma by Deep Sequencing as a Potential Predictor of Disease Progression in NSCLC." Oral presentation at World Conference on Lung Cancer, Yokohama, Japan. October 15-18, 2017.

  • JJ Lee, JF Palma, L Yao, AF Lovejoy, S Yaung, D Zhang, N Wingate-Pearse, M Yau, C Williams, M Pimentel, A Munoz, K Mayol, C Mancao, A Nicholas, N Sommer, JC Bendell, H Hurwitz, U Rohr. "Evaluation of clinical outcomes by analysis of mutations in tumor tissue and circulating plasma DNA using next-generation sequencing (NGS) from STEAM, a prospective, randomized, multicenter study in metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 35:11510, 2017. Poster presented and discussed at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 2-6, 2017.

  • M Diehn, AA Alizadeh, H Adams, JJ Lee, S Klassen, JF Palma, B Hinzman, AF Lovejoy, AM Newman, L Yao, S Yaung, A Balasubramanyam, U Rohr, A Rosenthal, R Kube, T Steinmuller, F Marusch, R Mantke, M Heise, M. "Early prediction of clinical outcomes in rescted II and III colorectal cancer (CRC) through deep sequencing of circulating tumor DNA (ctDNA)." Journal of Clinical Oncology 35:3591, 2017. Poster presented at American Society for Clinical Oncology Annual Meeting, Chicago, Illinois. June 2-6, 2017.

  • S Yaung, A Lovejoy, D Klass, F Casey, A Arcot, M Loyzer, W Chiu, N Azhar, S Beckert, M Lange, S Siemann, S Froehler, S Gunn, JF Palma. "Inter-site comparison of performance of an ultra-sensitive sequencing technology for circulating tumor DNA." 2017 American Association for Cancer Research Annual Meeting, Washington, D.C. April 1-5, 2017.

  • SJ Yaung, L Deng, N Li, JL Braff, GM Church, L Bry, HH Wang, GK Gerber. "Temporal functional metagenomics sequencing to improve microbial fitness in the mammalian gut." HST Forum, Boston, Massachusetts. April 16, 2015.

  • SJ Yaung, HH Wang, KM Esvelt, GM Church. "Engineering Gene Transfer Networks in the Human Microbiome." Wyss Institute Annual Retreat, Boston, Massachusetts. November 19, 2012.

  • PB Matthews, S Yaung, AN Azadani, N Jaussaud, C Jhun, JM Guccione, TS Guy, EE Tseng. "Pulmonary Autograft Wall Stress Calculation With Finite Element Modeling." Biennial Meeting of the Society for Heart Valve Disease, Berlin, Germany. June 27-30, 2009.

  • P Dhawan*, S Yaung*, H Uppal*, D Puppala, M Sweeney, J Murray, P Hajek, E Oquendo, C Wilson, N Priedigkeit, D Goldstein, D Misner, S Platz, R Capaldi, K Kolaja. "The Role of Mitochondrial Toxicity in the Cardiotoxicity of Small Molecule Kinase Inhibitors." Annual Meeting of the Society of Toxicology, Baltimore, Maryland. March 15-19, 2009.



  • KM Esvelt, S Yaung. "Precise microbiota engineering at the cellular level." US Patent Application 61/900002, PCT International Application WO 2015/069682, PCT/US2014/063994. Filed November 5, 2014.

  • GJ Xu, SJ Yaung. "Reader-less quantitative lateral flow assay." US Provisional Patent Application 61/609936. Filed March 12, 2012.