Recent Publications & Presentations

B. Q. Spring, K. Watanabe, T. Matsudaira, H. Wakimoto, S. Mallidi, and T. Hasan, “Chemoresistant glioblastoma stem-like cells respond to photodynamic therapy,” SPIE Photonics West: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, vol. Oral Presentation. pp. 9308-4, 2015.Abstract

Glioblastoma stem cells (GSCs) isolated from patients with newly diagnosed disease are potent tumor initiators that express biomarkers associated with stem cells. These stem-like cells are thought to drive treatment resistance and tumor recurrence. Preclinical models suggest that the GSC subpopulation becomes enriched and re-populates the tumor milieu following conventional therapies. This talk will discuss the use of photodynamic therapy to overcome treatment resistance in a preclinical model of human GSC neurosphere cell cultures.

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