Publications by Author: Stephen Arnason

2015
J. Hempstead, et al., “Enabling technology for photodynamic therapy in global health settings: battery-powered irradiation and smartphone-based imaging for ALA-PDT,” SPIE Photonics West: Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV, vol. Oral Presentation. pp. 9308-18, 2015.Abstract

Lack of access to effective cancer therapeutics in resource-limited settings is widely implicated in global cancer health disparities. Here we evaluate low-cost devices to enable photodynamic therapy (PDT) and associated photosensitizer imaging in regions with little or no access to electricity or medical infrastructure. We demonstrate the efficacy of a battery-powered LED-based device following aminolevulinic acid (ALA) induced accumulation of protoporphyrin IX (PpIX). We further evaluate the capability of a consumer smartphone coupled with a 405nm LED array and a PpIX emission filter to image PpIX fluorescence. Collectively this work suggests the feasibility of image-guided ALA-PDT in resource-limited settings.