Lack of access to effective cancer therapeutics in resource-limited settings is widely implicated in global cancer health disparities. Here we evaluate low-cost devices to enable photodynamic therapy (PDT) and associated photosensitizer imaging in regions with little or no access to electricity or medical infrastructure. We demonstrate the efficacy of a battery-powered LED-based device following aminolevulinic acid (ALA) induced accumulation of protoporphyrin IX (PpIX). We further evaluate the capability of a consumer smartphone coupled with a 405nm LED array and a PpIX emission filter to image PpIX fluorescence. Collectively this work suggests the feasibility of image-guided ALA-PDT in resource-limited settings.