Hello! I'm starting my lab at the Ragon Institute of Mass General, MIT, and Harvard this Sept 1. Check out the new lab website, at liulab.bio. 

I graduated in 2023 from Harvard Biophysics and the Harvard-MIT HST Medical Engineering and Medical Physics (MEMP) programs, advised by Fei Chen. I enjoy creating new ways to measure temporally and spatially dynamic cell interactions and am particularly interested in studying T and B-cell development. I am supported by the NSF Graduate Research Fellowship and have received an Impetus Grant to study the age-related decline of adaptive immunity.

I received my Bachelor of Science in chemical-biological engineering at MIT in 2017, minoring in biology and concentrating in literature. I worked in Robert Langer's lab with Armon Sharei on a microfluidic device for antigen delivery and Alex Shalek's lab with Jose Ordovas-Montanes on single-cell sequencing neuronal nuclei. 

sophialiu [at] g.harvard.edu  / CV /  Github  /  Google Scholar  /  LinkedIn  /  Twitter

Sophia Liu

Publications

Slide-TCR-seq

Spatially mapping T cell receptors and transcriptomes reveals distinct immune niches and interactions underlying the adaptive immune response

Liu, S.*, Iorgulescu, J. B.*, Li, S.*, Borji, M., Barrera-Lopez, I. A., Shanmugam, V., Lyu, H., Morriss, J. W., Garcia, Z. N., Murray, E., Reardon, D. A., Yoon, C. H., Braun, D. A., Livak, K. J., Wu, C. J., Chen, F. 
Immunity, 55, 1940-1952.e5. (2022).

Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity

Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity

Booty, M. G.*, Hlavaty, K. A.*, Stockmann, A., Tian, L., How, E., Subramanya, D., Venkitaraman, A., Yee, C., Ozay, E. I., Pryor, O., Smith, C., Volk, K., Blagovic, K., Vicente-Suarez, I., Yarar, D., Myint, M., Merino, A., Chow, J., Abdeljawad, T., An, H., Stokes, B., Liu, S., Mao, S., Heimann, M., von Andrian, U. H., Jensen, K. F., Langer, R. S., Knoetgen, H., Trumpfheller, C., Bernstein, H.,  Sharei, A., Loughhead, S. M. 
The Journal of Immunology, 208(4) 929-940(2021). 

Timestamps Schematic

RNA timestamps identify the age of single molecules in RNA sequencing

Rodriques, S.G.*, Chen, L.M.*, Liu, S., Zhong, E.D., Scherrer, J.R., Boyden, E.S., Chen, F.
Nature Biotechnology. (2020). 
bioRxiv doi: https://doi.org/10.1101/2020.02.08.939983

PDF  /  Primer Talk

TRACE Schematic

Efficient, continuous mutagenesis in human cells using a pseudo-random DNA editor

Chen, H., Liu, S.*, Padula, S.*, Griswold, K., Lin, A., Zhao, T., Marshall, J. L., Chen, F.
Nature Biotechnology, 38, 165-168 (2019).

PDF  /  Nature Bioengineering Blog

SQZ Schematic

Ex Vivo Cytosolic Delivery of Functional Macromolecules to Immune Cells

Sharei, A.*, Trifonova, R.*, Jhunjhunwala, S.*, Hartoularos, G., Eyerman, A.T., Lytton-Jean, A., Angin, M., Sharma, S. , Poceviciute, R., Mao, S., Heimann, M., Liu, S., Talkar, T., Khan, O. F., Addo, M., von Andrian, U. H., Anderson, D. G., Langer, R., Lieberman, J., Jensen, K. F. 
PLOS One, 10(4): e0118803 (2015).

PDF

Patents

Miscellaneous

I enjoy skiing, running, reading sci-fi & fantasy, and have dabbled in taking photographs, writing, bullet chess, and making ceramics.