I am moving to the University of Michigan, Ann Arbor as an Assistant Professor in the Department of Biomedical Engineering next January, 2017. Please visit us at sriramlab.org
I am a Junior Fellow at Harvard. My research is in Systems Biology with a focus on metabolism and regulation. I also develop computational tools that enable omics-based drug discovery and metabolic engineering.
I did my PhD in Biophysics and Computational Biology at the University of Illinois at Urbana-Champaign and partly at the Institute for Systems Biology, Seattle. I got my Bachelor of Technology degree in Biotechnology from Anna University in 2008.
Awards, Grants and Honors
- William F. Milton Fund, Harvard University, 2014-2015 (PI)
- Lemelson MIT Illinois Student Award for innovation - finalist, 2012 (Award Poster pdf)
- Robert Emerson Fellowship (2008-2009)
Recent Media Coverage
Saul, M.C, Seward C, Troy J, Zhang H, Sloofman L, Lu X, Weisner P, Caetano-Anolles D, Sun H, Zhao D, Chandrasekaran S, Sinha S, and Stubbs L. “Transcriptional regulatory dynamics set the stage for a coordinated metabolic and neural response to social threat in mice” (in review)
Zhang J*, Ratanasirintrawoot R*, Chandrasekaran S, [22 authors], Collins J.J, Daley G.Q, LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency, Cell Stem Cell, 2016. Highlighted in Cell Stem Cell, "Metabolic RemodeLIN of Pluripotency"
Chandrasekaran S, Cokol-Cakmak M, Sahin N, Yilancioglu K, Kazan H, Collins J.J and Cokol M, “Chemogenomics and Orthology-based Design of Antibiotic Combination Therapies”, Molecular Systems Biology (Cover Article), 2016. Most read article in Molecular Systems Biology (as of July 2016). Featured in MedChemNet Video Interview. (Download INDIGO here)
Sobotka J, Daley M, Chandrasekaran S, Rubin B, Thompson G. “Structure and function of gene regulatory networks associated with worker sterility in honeybees", Ecology and Evolution, 2016
Chandrasekaran S*, Rittschof C*, Djukovic D, Gu H, Raftery D, Price N.D, and Robinson G.E, “Aggression is Associated with Aerobic Glycolysis in the Honey Bee Brain”, Genes Brain and Behavior, 2015.(Top 5 most cited articles in 2015 in Genes Brain and Behavior)
Brooks A.N, Reiss D.J, Allard A, Wu W, Salvanha D.M, Plaisier C, Chandrasekaran S, Pan M, Kaur A, Baliga N.S. A system‐level model for the microbial regulatory genome, Molecular Systems Biology, 2014
Chandrasekaran S, “Predicting Phenotype from Genotype through Reconstruction and Integrative Modeling of Metabolic and Regulatory Networks”, Systems and Synthetic Biology: A Systematic Approach (ed V.V.Kulkarni/G.B.Stan/K.S.Raman), 2014
Chandrasekaran S, “Transcriptional Regulation Of Metabolism And Behavior: Insights From Reconstruction And Modeling Of Complex Biochemical Networks” (dissertation), 2013
Chandrasekaran S and N.D. Price, “Metabolic Constraint-based Refinement of Transcriptional Regulatory Networks”, PLOS Computational Biology, 2013. Highlighted in Nature Genetics and Genomeweb.
- Simeonidis E, Chandrasekaran S, Price ND. “A guide to integrating transcriptional regulatory and metabolic networks using PROM (Probabilistic Regulation of Metabolism)”, Methods in Molecular Biology: Systems Metabolic Engineering (ed: Hal Alper), 2012.
- Sung J, Wang Y, Chandrasekaran S, Witten DM, and ND Price, “Molecular signatures from omics data: from chaos to consensus”. Biotechnology Journal, 2012.
- Chandrasekaran S, Ament S.A, Eddy J.A, Rodriguez-Zas S.R, Schatz B.R, Price N.D, and Robinson G.E, "Behavior-specific changes in transcriptional modules lead to distinct and predictable neurogenomic states", PNAS, 2011 (Cover Article). Highlighted in PNAS "Systems biology meets behavior", Russel Fernald
- Chandrasekaran S and N.D. Price, "Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis," PNAS, 2010
- L.B. Edelman, Chandrasekaran S, and N.D. Price, "Systems biology of embryogenesis”, Reproduction, Fertility, and Development, 2010.
Other Awards and Activities
- President, Illinois Biophysics Society, 2010 to 2012
- Editor of the IBS Newsletter (2010, 2009)
- Co-chair, Centre for Biophysics and Computational Biology symposium (2010)
- Outstanding Oral Presentation Award, CMBTG Symposium, UIUC, 2010
- Best Oral Presentation (2nd Place), Resonance Symposium, Anna University, 2005
- First Class with Distinction, for Bachelor of Technology in Biotechnology, Anna University
- Biophysics Travel Grant Award, 2010
- Q-Bio Conference Travel Fellowship, 2010
Seminars and Invited Presentations
- University of Michigan, Ann Arbor, Department of Biomedical Engineering, ‘Drugs, Bugs and Bees: Computational Approaches for Combinatorial Biology’, 2016
- California Institute of Technology, Department of Biology and Biological Engineering, ‘Systems Approaches for Combinatorial Biology’, 2016
- Broad Institute, Infectious Disease Program Seminar, ‘Large-Scale Inference of Non-Linear Antibiotic Interactions using Chemogenomic Profiles’, 2015
- Broad Institute, Computational Biology Program Meeting, ‘Chemical-genetic Inference of Antibiotic Interactions for Combination Therapies’, 2015
- Harvard Medical School, Brigham and Women’s Hospital, Channing Division of Network Medicine, ‘Predicting Cell Metabolism and Phenotype Using Genome-Scale Network Models’, 2015
- University of Illinois, Urbana, Department of Bioengineering, 2014. ‘Predicting Cell Metabolism and Phenotype Using Genome-Scale Network Models’
- Harvard Medical School, Department of Systems Biology, ‘Theory Lunch’, 2014. ‘Brain Metabolic States and Behavior’
- Northeastern University, Center for Complex Network Research, 2014. ‘Brain Gene Regulatory Networks and Social Behavior’
- Broad Institute, Coordinated Biological Research Meeting, 2014. ‘Brain Metabolism and Social Behavior in Honeybees’.
- Harvard University, Evolutionary Dynamics, Math 243, 2014. Guest lecture on ‘Molecular Networks and Behavior’
- Harvard University, Center for Systems Biology, ‘Bauer Forum’, 2013. ‘Genome-scale Network Models of Metabolism and Social Behavior’
- Purdue University, 2012. ‘Linking Biochemical Networks with Genomic and Phenotypic Data Identifies Functional Regulatory Interactions’
- Institute for Systems Biology, Seattle, RIP talk, 2012. ‘From Genotype to Phenotype: Linking Biochemical Networks with Genomic and Phenotypic Data to build predictive Network Models’
- Massachusetts Institute of Technology, EurekaFest 2012. ‘Computational platform for next-generation diagnostics and bio-engineering’ (invited showcase)
- Systems Biology short course at Institute for Systems Biology, Seattle, 2012. Guest lecture on ‘Metabolic Networks: A Systems Approach’
- Institute for Systems Biology, Seattle, 2011. ‘Reconstructing Predictive Network Models of Cellular Behavior’
- Center for Biotechnology, Anna University, 2011. ‘Next-Generation Diagnostics using Systems Biology’ (invited alumni talk)
Topic: Chemogenomic Inference of Antibiotic Interactions for Combination Therapies
Biomedical Engineering Society Annual Meeting (BMES), Tampa FL, 2015
Annual Meeting of the American Institute of Chemical Engineers (AICHE), Salt Lake City, Utah, 2015 (abstract)
Topic: Gene Expression and Metabolism Integrated for Network Inference
Conference on Predicting Cell Metabolism and Phenotypes, SRI, Menlo Park, CA, 2013
Systems Bioinformatics Workshop, Seattle, 2012
Constraint-Based Reconstruction and Analysis (COBRA) 2014, Charlottesville, VA
Sixth International Workshop on Bio-Design Automation (IWBDA) 2014 , Boston, MA
- Annual Meeting of the American Institute of Chemical Engineers (AICHE), Pittsburg, PA, 2012 (abstract)
Topic: Integrative Modeling of Metabolic and Regulatory Networks
Institute for Systems Biology-Seattle Biomed Joint Symposium, (Lightning Talk) 2012
Biomedical Engineering Society Annual Meeting, Hartford CT, 2011
Annual Meeting of the American Institute of Chemical Engineers, Salt Lake City, Utah, 2010
‘How small perturbations can lead to global changes - Predicting phenotype from genetic perturbations in silico’. Received 'Outstanding Oral Presentation Award' for the '23rd Annual Cell & Molecular Biology/Molecular Biophysics Research Symposium', 2010
Biomedical Engineering Society Annual Meeting, Austin, Texas, 2010
Topic: Transcriptional Regulatory Networks in the Honeybee Brain
"Brain transcriptional regulatory network quantitatively predicts behavior-specific gene expression." Quantitative Biology Conference, Santa Fe, NM, Aug 2011. (Received the Q-bio Conference Fellowship)
How to pronounce my name?
Sri - Ram - Chandra - Sekaran
Pronunciation: Shri (rhymes with free) - Ram (rhymes with palm) - CHUN-drah-say-car-un
78 Mount Auburn Street,
Cambridge MA, 02138
Ph: 617 496 0048