All Publications

109. Deng, X., Zhang, Y., Rong, J., Kumata, K., Shao, T., Wang, G., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Shao, Y., Josephson, L., Sun, S., Zhang, M.-R., and Liang, S. H.  “Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4” Tetrahedron Letters, 2020, 61, 152060.  DOI: https://doi.org/10.1016/j.tetlet.2020.152060

108. Chen, Z., Chen, J., Mast, N., Rong, J., Deng, X., Shao, T., Fu, H., Yu, Q., Sun, J., Shao, Y., Josephson, L., Collier, T. L., Pikuleva, I. and Liang, S. H. “Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' 11CO2 fixation method” Bioorganic & Medicinal Chemistry Letters, 2020, ASAP. DOI: 10.1016/j.bmcl.2020.127068.

107. Xiao, Z., Wang, L., Wei, J., Ran, C., Liang, S. H., Shang, J., Chen, G. Y. and Zheng, C. “Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds” Chemical Communications, 2020, ASAP, DOI: 10.1039/d0cc00451k.

106. Shao, T., Chen, Z., Belov, V., Wang, X., Rwema, S., Kumar, V., Fu, H., Deng, X., Rong, J., Yu, Q., Lang, L., Lin, W., Josephson, L., Samir, A., Chen, X., Chung, R. and Liang, S. H.  “[18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis” Journal of Hepatology, 2020, accepted.

105. Liang, J., Huang, Y. Y., Zhou, Q., Cao, Y., Li, Z., Wu, D., Yu, S., Guo, L., Chen, Z., Huang, L., Liang, S. H., He, X., Wu, R. and Luo H. B. "Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia” Journal of Medicinal Chemistry, 2020, accepted.

104. Varlow, C., Murrell, E., Holland, J. P., Kassenbrock, A., Shannon, W., Liang, S. H., Vasdev, N. and Stephenson, N. A. “Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's Disease” Molecules, 2020, accepted.

103. Lin, X. P., Xiao, Z. Z., Chen, T., Liang, S. H. and Guo, H. Q. “Glucose Metabolism on Tumor Plasticity, Diagnosis and Treatment” Frontiers in Oncology, 2020, accepted.

102. Chen, J., Gan, J., Sun, J., Chen, Z., Fu, H., Rong, J., Deng, X., Shang, J., Gong, J., Collier, L., Wang, L., Xu, H. and Liang, S. H. “Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors” Tetrahedron Letters, 2020, accepted.

101. Yu, Q., Kumata, K., Li, H., Zhang, Y., Chen, Z., Zhang, X., Shao, T., Hatori, A., Yamasaki, T., Xie, L., Hu, K., Wang, G., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H. “Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126879. DOI: https://doi.org/10.1016/j.bmcl.2019.126879

100. Liang, S. H., Wang, L., Stephenson, N. A., Rotstein, B. H., and Vasdev, N. “Facile 18F Labeling of Non-activated Arenes via a Spirocyclic Iodonium(III) Ylide Method and its Application in the Synthesis of the mGluR5 PET Radiopharmaceutical [18F]FPEB” Nature Protocol, 2019, 14, 1530-1545.

99. Hu, K., Yang, Z.M., Zhang, L.L., Xie, L., Wang, L., Xu, H., Josephson, L., Liang, S.H., Zhang, M.-R. “Boron agents for neutron capture therapy” Coordination Chemistry Reviews, 2019, accepted.

98. Yu,  H., Zhao, W., Zhou, Y., Cheng, G-J., Sun, M., Wang, L., Yu, L., Ran, C. and Liang, S. H. "Salen-based Bifunctional Chemosensor for Copper (II) Ions: Inhibition of Copper-induced Amyloid-β Aggregation" Analytica Chimica Acta, 2019, accepted.

97. Bernard-Gauthier, V., Mossine, A.V., Knight, A., Patnaik, D., Zhao, W., Cheng, C., Krishnan, H.S., Xuan, L.L., Chindavong, P.S., Reis, S.A., Chen, J.M., Shao, X., Stauff, J., Arteaga, J., Sherman, P.S., Salem, N., Bonsall, D., Amaral, B., Varlow, C., Wells, L., Martarello, L., Patel, S., Liang, S.H., Kurumbail, R.G., Haggarty, S.J., Scott, P.J.H., Vasdev, N. "Structural Basis for Achieving GSK-3beta Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery" Journal of Medicinal Chemistry, 2019, ASAP, DOI: 10.1021/acs.jmedchem.9b01030.

96. Chen, Z., Mori, W., Fu, H., Schafroth, M. A., Hatori, A., Shao, T., Zhang, G., Van, R. S., Zhang, Y., Hu, K., Fujinaga, M., Wang, L., Belov, V., Ogasawara, D., Giffenig, P., Deng, X., Rong, J., Yu, Q., Zhang, X., Papisov, M. I., Shao, Y., Collier, T. L., Ma, J.-A., Cravatt, B. F., Josephson, L., Zhang, M.-R., and Liang, S. H. "Design, Synthesis and Evaluation of 18F-labeled Monoacylglycerol lipase Inhibitors as Novel Positron Emission Tomography Probes" Journal of Medicinal Chemistry, 2019, 62, 8866-8872. DOI: 10.1021/acs.jmedchem.9b00936

95. Nie, B., Wang, L., Hu, Y., Liang, S., Tan, Z., Chai, P., Tang, Y., Shang, J., Pan, Z., Zhao, X., Zhang, X., Gong, J., Zheng, C., Xu, H., Wey, H.-Y., Liang, S. H., and Shan, B. “A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model” NeuroImage, 2019, ASAP, DOI: 10.1016/j.neuroimage.2019.116163

94. Wang, L., Yao, S., Tang, R., Zhu, H., Zhang, L., Gong, J., Chen, Q., Collier, T. L., Xu, H.,  and Liang, S. H.  “A concisely automated synthesis of TSPO radiotracer [18F]FDPA based on spirocyclic iodonium ylide (SCIDY) method and validation for human use” Journal of Labelled Compounds and Radiopharmaceuticals, 2019, accepted.

93. Chen, Z., Shao, T., Gao, W., Fu, H., Collier, T. L., Rong, J., Deng, X., Yu, Q., Zhang, X., Davenport, A. T., Daunais, J. B., Wey, H. Y., Shao, Y., Josephson, L., Qiu, W., and Liang, S. H.  "Synthesis and Preliminary Evaluation of [11C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease" ChemMedChem, 2019, 14, 1580-1585.

92. Zhang, B., Fraser, B. H., Klenner, M. A., Chen, Z., Liang, S. H., Massi, M., Robinson, A. J. and Pascali, G. "[18F]Ethenesulfonyl fluoride as a novel radiofluoride relay reagent" Chemistry - A European Journal, 2019, accepted. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201900930

91. Chen, Z., Mori, W., Deng, X., Cheng, R., Ogasawara, D., Zhang, G., Schafroth, M. A., Dahl, K., Fu, H., Hatori, A., Shao, T., Zhang, Y., Yamasaki, T., Zhang, X., Rong, J., Yu, Q., Hu, K., Fujinaga, M., Xie, L., Kumata, K., Gou, Y., Chen, J., Gu, S., Bao, L., Wang, L., Collier, T. L., Vasdev, N., Shao, Y., Ma, J.-A., Cravatt, B. F., Fowler, C., Josephson, L., Zhang, M.-R. and Liang, S. H.  "Design, Synthesis and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a ‘Tail Switching’ Strategy on a Piperazinyl Azetidine Skeleton"  Journal of Medicinal Chemistry, 2019, 62, 3336-3353.  DOI: 10.1021/acs.jmedchem.8b01778.  

90. Ran, C., Yang, J., Cheng, R., Fu, H., Yang, J., Kumar, M., Lu, J., Xu, Y., Liang, S. H., and Cui, M.  "Half-curcumin analogues as PET imaging probes for Amyloid beta species" Chemical Communications, 2019, ASAP, DOI: 10.1039/c8cc10166c.

89. Shao, T., Josephson, L. and Liang, S. H. "Molecular Probes for Diagnosis and Staging of Non-Alcoholic Fatty Liver Disease" Molecular Imaging, 2019, accepted.

88. Fu, H., Tang, W., Chen, Z., Belov, V., Zhang, G., Shao, T., Zhang, X., Yu, Q., Rong, J., Deng, X., Han, W., Myers, S., Giffenig, P., Wang, L., Josephson, L., Shao, Y., Davenport, A., Daunais, J., Papisov, M., Yuan, H., Li, Z., Traynelis, S. and Liang, S. H.   "Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([18F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain"  ACS Chemical Neuroscience, 2019, 10, 2263-2275.  DOI: 10.1021/acschemneuro.8b00591.

87. Deng, X., Hatori, A., Chen, Z., Kumata, K., Shao, T., Zhang, X., Yamasaki, T., Hu, K., Yu, Q., Ma, L., Wang, G., Wang, L., Shao, Y., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H.  "Synthesis and Preliminary Evaluation of 11C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4" ChemMedChem, 2019, ASAP, DOI: 10.1002/cmdc.201800710.

86. Zhao, S., Wang, H., Sun, S., Guo, H., Chen, Z., Wang, J., Wang, L., Liang, S. H., and Wang, G. "An efficient synthesis of 2-isoxazolines from α-haloketone oximes and dimethyl sulfonium salts" Tetrahedron Letters, 2019, ASAP, DOI:10.1016/j.tetlet.2018.12.062.

85. Lin, J-H., Deng, X., Xiao, J-C., and Liang, S. H. "Recent advances in 18F-labeling of trifluoromethylthiolation", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2019, accepted.

84. Rong, J., Chen, Z., Vasdev, N. and Liang, S. H. "Aryl-18F bond formation from nucleophilic [18F]fluoride", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2019, accepted.

83. Josephson, L., Stratman, N., Liu, Y., Qian, F., Liang, S. H., Vasdev, N. and Patel, S.  "The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils" Mol. Imaging, 2018, ASAP, DOI: 10.1177/1536012118796297.

82. Fu, H., Chen, Z., Josephson, L., Li, Z. and Liang, S. H.   "Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-methyl-D-aspartate (NMDA), alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) and Kainate Receptors"  J. Med. Chem., 2019, 62, 403-419. PMID: 30110164

81. Chen, Z., Mori, W., Zhang, X., Yamasaki, T., Dunn, P. J., Zhang, G. W., Fu, H., Shao, T., Zhang, Y., Hatori, A., Ma, L., Fujinaga, M., Xie, L., Deng, X., Li, H., Yu, Q., Rong, J., Josephson, L., Ma, J., Shao, Y., Tomita, S., Zhang, M. R., and Liang, S. H.    "Synthesis and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazol-2-ones for imaging studies towards γ8-dependent transmembrane AMPA receptor regulatory protein."   Eur. J. Med. Chem., 2018, 157, 898-908. PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245653/

80. Cheng, S., Jacobson, O., Zhu, G., Chen, Z., Liang, S. H., Tian, R., Yang, Z., Niu, G., Zhu, X and Chen, X.  PET imaging of EGFR expression using an 18F-labeled RNA aptamer.  Eur. J. Nucl. Med. Mol. Imaging, 2018, ASAP, DOI: 10.1007/s00259-018-4105-1.

79. Zheng, C., Wang, Y., Xu, Y., Chen, Z., Chen, G., and Liang, S. H.   "Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide"  Org. Lett., 2018, ASAP. DOI: 10.1021/acs.orglett.8b01885.

78. Deng X, Rong J, Wang L, Vasdev N, Zhang L, Josephson L, and Liang S. H.  "Chemistry for Positron Emission Tomography: Recent Advances in 11C-, 18F-, 13N- and 15O-labeling Reactions"  Angew. Chem. Int. Ed., 2018, ASAP. DOI: 10.1002/anie.201805501.

77. Rong, J. and Liang, S. H. "Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography", in Synthetic Organofluorine Chemistry, Springer, New York, 2018, accepted.

76. Yamasaki, T., Mori, W., Zhang, Y., Hatori, A., Fujinaga, M., Wakizaka, H., Kurihara, Y., Wang, L., Nengaki, N., Ohya, T., Liang, S. H. and Zhang, M-R. "First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303" NeuroImage, 2018, accepted. DOI: 10.1016/j.neuroimage.2018.05.015.

75. Collier, T. L.; Dahl, K.; Stephenson, N. A.; Holland, J. P.; Riley, A.; Liang, S. H. and Vasdev, N.  "Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry" J Fluorine Chem, 2018, accepted.

74. Cheng, R.; Mori, W.; Ma, L.; Alhouayek, M.; Hatori, A.; Zhang, Y.; Ogasawara, D.; Yuan, G.; Chen, Z.; Zhang, X.; Shi, H.; Yamasaki, T.; Xie, L.; Kumata, K.; Fujinaga, M.; Nagai, Y.; Minamimoto, T.; Svensson, M.; Wang, L.; Du, Y.; Ondrechen, M.; Vasdev, N.; Cravatt, B. F.; Fowler, C.; Zhang, M-R. and Liang, S. H.  "In vitro and in vivo evaluation of 11C-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies"  J Med Chem, 2018, 61, 2278-2291.   DOI: 10.1021/acs.jmedchem.7b01400. [link]

73. Krishnan, H. S.; Bernard-Gauthier, V.; Placzek, M. S.; Dahl, K.; Narayanaswami, V.; Livni, E.; Chen, Z.; Yang, J.; Collier, T. L.; Ran, C.; Hooker, J. M.; Liang, S. H. and Vasdev, N. “Metal protein-attenuating compound for PET neuroimaging: synthesis and preclinical evaluation of [11C]PBT2” Mol Pharm, 2018, 15, 695-702. DOI: 10.1021/acs.molpharmaceut.7b00936 [link]

72. Collier, T. L.; Liang, S. H.; Mann, J. J.; Vasdev, N. and Kumar, J. S. D. "Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors" Beilstein J. Org. Chem., 2017, 13, 2922-2927. DOI: 10.3762/bjoc.13.285 [full-text]

71. Bernard-Gauthier, V.; Legage, M.; Waengler, B.; Bailey, J. A.; Liang, S. H.; Perrin, D.; Vasdev, N. and Schirrmacher, R. "Recent advances in fluorine-18 radiochemistry: Focus on B-18F, Si-18F, Al-18F and C-18F radiofluorination via spirocyclic iodonium ylides" J Nucl. Med., 2017, asap. DOI: 10.2967/jnumed.117.197095

70. Zhang, X.; Kumata, K.; Yamasaki, T.; Cheng, R.; Hatori, A.; Ma, L.; Zhang, Y.; Wang, L.; Kang, H. J.; Sheffler, D. J.; Cosford, N. D. P.; Zhang, M-R & Liang, S. H. "Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide for Imaging of Metabotropic Glutamate Receptor 2" ACS Chem. NeuroSci. 2017, 8, 1937-1948. [link] [full-text]

69. Collier, T. L.; Maresca K. P.; Normandin, M. D.; Richardson, P.; McCarthy, T. J.; Liang, S. H.; Waterhouse, R. N. & Vasdev, N. "Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET" Mol. Imaging, 2017, DOI: 10.1177/1536012117736669. [link]

68. Bernard-Gauthier, V.; Collier, T. L.; Liang, S. H. & Vasdev, N. "Discovery of PET Radiopharmaceuticals at the Academia-Industry Interface" Drug Discov. Today Technol., 2017, accepted. [link]

67. Ran, C.; Albrecht, D. S.; Bredella, M. A.; Yang, J.; Yang, J.; Liang, S. H.; Cypress, A. M.; Loggia, M. L.; Atassi, N. & Moore, A. "PET imaging of human brown adipose tissue with TSPO tracer [11C]PBR28" Mol. Imaging Biol., 2017, accepted. [link]

66. Yuan, G.; Jankins, T. C.; Patrick, C. G.; Philbrook, P.; Sears, O.; Hatfield, S.; Sitkovsky, M.; Vasdev, N.; Liang, S. H.; Ondrechen, M. J.; Pollastri, M. P. & Jones, G. B. "Fluorinated adenosine A2A receptor antagonists inspired by Preladenant as potential cancer immunotherapeutics" Int. J. Med. Chem., 2017, article ID 4852537. [link]

65. Krishnan, H.; Ma, L.; Vasdev, N. & Liang S. H. "18F-Labeling of Sensitive Biomolecules for Positron Emission Tomography" Chem. Eur. J. 2017, 23, 15553 - 15577. [link] [full-text]

64. Yang, J.; Yang, J.; Wang, L.; Moore, A.; Liang, S. H. & Ran, C. "Synthesis-Free PET Imaging of Brown Adipose Tissue and TSPO via Combination of Disulfiram and 64CuCl2" Sci. Rep. 2017, 7, 8298. [link]

63. Dahl, K.; Collier, T. L.; Cheng, R.; Zhang, X.; Sadovski, O.; Liang, S. H. and Vasdev, N. "“In-Loop” [11C]CO2-Fixation: Prototype and Proof-of-Concept" J. Labelled Comp. Radiopharm. 2017, 60, accepted. [link]

62. Collier, T. L.; Normandin, M. D.; Stephenson, N. A.; Livni, E.; Liang, S. H.; Wooten, D. W.; Esfahani, S. A.; Stabin, M. G.; Mahmood, U.; Chen, J.; Wang, W.; Maresca, K.; Waterhouse, R. N.; El Fakhri, G.; Richardson, P. & Vasdev, N. "Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib" Nat. Commun. 2017, 8, 15761. DOI:  10.1038/ncomms15761 [link]

  • Check "SCIDY" page for novel 18F-labeling methodology.

61. Ma, L.; Placzek, M. S.; Hooker, J. M.; Vasdev, N. & Liang, S. H. "[11C]Cyanation of arylboronic acids in aqueous solutions" Chem. Commun. 2017, 53, 6597-6600. [link] [full-text]

  • Highlighted on "ChemViews Magazine" by Wiley-VCH and ChemPubSoc Europe in June 2017!
  • Highlighted on "Synfacts" by Thieme August 2017!
  • Highlighted on "Xmol" news in June issue 2017!

60. Wang, L.; Cheng, R.; Fujinaga, M.; Yang, J.; Zhang, Y.; Hatori, A.; Kumata, K.; Yang, J.; Vasdev, N.; Du, Y.; Ran, C.; Zhang, M-R. & Liang, S. H. "A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation" J. Med. Chem. 2017, 60, 5222-5227. [link] [full-text]

  • Highlighted on "Xmol" news in Ootober issue 2017!

59. Zheng, J.; Cheng, R.; Lin, J-H.; Yu, D-H.; Ma, L.; Jia, L.; Zhang, L.; Wang, L.; Xiao, J-C. & Liang, S. H. “An unconventional mechanistic insight on SCF3 formation from difluorocarbene: Preparation of 18F-labeled α-SCF3 carbonyl compounds” Angew. Chem. Int. Ed., 2017, in press. [link] [full-text]

  • Highlighted on "Atlas of Science" website in March 2017!
  • Highlighted on "Xmol" news in April issue 2017!

58. Hu, K.; Patnaik, D.; Collier, T. L.; Lee, K. N.; Gao, H.; Swoyer, M. R.; Rotstein, B. H.; Krishnan, H. S.; Liang, S. H.; Wang, J.; Yan, Z.; Hooker, J. M.; Vasdev, N.; Haggarty, S. J. & Ngai, M-Y. “Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3b Ligands for Positron Emission Tomography Imaging” ACS Med. Chem. Lett. 2017, in press. [link]

57. Yuan, G.; Wang, F.; Stephenson, N. A.; Wang, L.; Rotstein, B. H.; Vasdev, N.; Tang, P. & Liang, S. H. "Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation" Chem. Commun. 2017, 53, 126-129. [link]

56. Yang, J.; Yang, J.; Liang, S. H.; Xu, Y.; Moore, A. & Ran. C.   "Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification" Sci. Rep. 2016, 6, 35613. [link]

55. Yuan, Z.; Cheng, R.; Chen, P.; Liu, G. & Liang, S. H.   "Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines" Angew. Chem. Int. Ed. 2016, 55, 11882-11886. [link]

  •    Highlighted on "Xmol" news in Febrary issue 2017! 
  •    also check 'SCIDY' page.

54. Rotstein, B. H.; Placzek, M. S.; Krishnan, H. S.; Pekosak, A.; Collier, T. L.; Wang, C.; Liang, S. H.; Burstein, E. S.; Hooker, J. M. & Vasdev, N.    "Preclinical PET neuroimaging of Preclinical PET neuroimaging of [11C]bexarotene" Molecular Imaging, 2016, 15, 1-5. [open access] [full-text]

53. Yuan, G.;  Jones, G. B.; Vasdev, N. & Liang, S. H.   "Radiosynthesis and preliminary PET evaluation of 18F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1, 2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors" Bioorg. Med. Chem. Lett. 2016, 26, 4857-4860. [link]

  •    also check 'SCIDY' page.

52. Shi, H.; Braun, A.; Wang, L.; Liang, S. H.*; Vasdev, N* & Ritter, T.*   "Practical Synthesis of 18F-Difluoromethylarenes from Aryl (Pseudo) Halides" Angew. Chem. Int. Ed. 2016, 55, 10786-90.  [link]

51. Liang, S. H.;  Chen, M. J.; Normandin, M. D.; Chang, J. S.; Chang, G. C.; Taylor, C. K.; Trapa, P.; Plummer, M. S.; Para, K. S.; Conn, E. L.; Lopresti-Morrow, L.; Lanyon, L. F.; Cook, J. M.; Richter, K. E. G.; Nolan, C. E.; Schachter, J. B.; Janat, F.; Che, Y.; Shanmugasundaram, V.; Lefker, B. A.; Enerson, B. E.; Livni, E.; Wang, L.; Guehl, N.; Patnaik, D.; Wagner, F. F.; Perlis, R.; Holson, E. B.; Haggarty, S. J.; El Fakhri, G.; Kurumbail, R. G. & Vasdev, N.  "Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) that Modulates Tau Phosphorylation in Brain: Translation for PET Neuroimaging" Angew. Chem. Int. Ed. 2016, 55, 9601-5.   [link]

  •    Featured as "Very Important Paper" (VIP) !

50. Rotstein, B. H.; Liang, S. H.; Placzek, M. S.; Hooker, J. M.; Gee, A. D.; Dollé, F.; Wilson, A. A. & Vasdev, N.  "11C=O Bonds Made Easily for Positron Emission Tomography Radiopharmaceuticals" Chem. Soc. Rev. 2016, 45, 4708-26. [link]

49. Rotstein, B. H.; Wang, L.; Liu, R. Y.; Patteson, J.; Kwan, E. E.; Vasdev, N. & Liang, S. H.  "Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides" Chem. Sci. 2016, 7, 4407 - 4417.      [full-text]

  •    also check 'SCIDY' page.

48. Wang, L.; Mori, W.; Cheng, R.; Yui, J.; Hatori, A.; Ma, L.; Zhang, Y.; Rotstein, B. H.; Fujinaga, M.; Shimoda, Y.; Yamasaki, T.; Xie, L.; Nagai, Y.; Minamimoto, T.; Higuchu, M.; Vasdev, N.; Zhang, M.-R. & Liang, S. H.    "Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase" Theranostics 2016, 6, 1145-1159.    [full-text]

47. Rashidian, M.; Wang, L.; Eden, J. G.; Jacobsen, J.; Hossain, I.; Wang, Q.; Victoria, G. D.; Vasdev, N.; Ploegh, H. & Liang, S. H.    "Enzyme-Mediated Modification of Single Domain Antibodies for Imaging Modalities with different Characteristics" Angew. Chem. Int. Ed. 2016, 55, 528-533.   [full-text]

46. Wang, L.; Yui, J.; Wang, Q.; Zhang, Y.; Mori, W.; Shimoda, Y.; Fujinaga, M.; Kumata, K.; Yamasaki, T.; Hatori, A.; Rotstein, B. H.; Collier, T. L.; Ran, C.; Vasdev, N.; Zhang, M. -R. & Liang, S. H.    "Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([11C]MPPO) Based on alpha-Ketoheterocyclic Scaffold" ACS Chem. Neurosci. 2016, 7, 109-18.   [full-text]

45. Kassenbrock, A.; Vasdev, N. & Liang, S. H.    "Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors" Curr. Top. Med. Chem. 2016, 16, 1830-42.     [full-text]

44. Wang, L.; Jacobsen, O.; Avdic, D.; Rotstein, B. H.; Weiss, I. D.; Collier, L.; Chen, X.; Vasdev, N. & Liang, S. H. "Ortho-stabilized 18F-azido click agents and application in PET imaging of single-stranded DNA aptamer" Angew. Chem. Int. Ed. 2015, 54, 12777-81.  [full-text]

  •    Highlighted on "Atlas of Science" in October 2015;
  •    Featured on “Pubfacts” website! 
  •    also check 'SCIDY' page.

43. Zheng, J.; Wang, L.; Lin, J.-H.; Xiao, J.-C. & Liang, S. H. "Difluorocarbene-derived Trifluoromethylthiolation and [18F]Trifluoromethylthiolation of Aliphatic Electrophiles" Angew. Chem. Int. Ed. 2015, 54, 13236-40.   [full-text]

  •    Highlighted on "Atlas of Science" website in October 2015!

42. Jacobson, O.; Weiss, I.; Wang, L.; Wang, Z.; Yang, X.; Dewhurst, A.; Ma, Y.; Zhu, G.; Niu, G.; Kiesewetter, D. O.; Vasdev, N.; Liang, S. H.* & Chen, X.*   "18F-labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression" J. Nucl. Med. 2015, 56, 1780-5;    [full-text]

  •    also check 'SCIDY' page. 

41. Stephenson, N. A.; Holland, J. P.; Kassenbrock, A.; Yokell, D. L.; Livni, E.; Liang, S. H. & Vasdev, N. "Iodonium Ylide–Mediated Radiofluorination of 18F-FPEB and Validation for Human Use" J. Nucl. Med. 2015, 56, 489-92. [full-text]

  •    also check 'SCIDY' page.

40. Calderwood, S.; Collier, T. L.; Gouverneur, V.; Liang, S. H.* & Vasdev, N.* "Synthesis of 18F-arenes from spirocyclic iodonium(III) ylides via continuous-flow microfluidics" J. Fluorine Chem. 2015, 178, 249-253. [full-text]

  •   also check 'SCIDY' page.

39. Liang, S. H. & Vasdev, N. "Total Radiosynthesis: Thinking Outside 'the Box'" Aust. J. Chem. 2015, 68, 1319-28.  [full-text]

38. Liang, S. H.; Southon, A. G.; Fraser, B. H.; Krause-Heuer, A. M.; Zhang, B.; Shoup, T. M.; Lewis, R.; Volitakis, I.; Han, Y.; Greguric, I.; Bush, A. I. & Vasdev, N. "Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease" ACS Med. Chem. Lett. 2015, 6, 1025-9.   [full-text]

37. Feng, M.; Tang, B.; Liang, S. H.* & Jiang, X.* "Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry" Curr. Top. Med. Chem. 2015, 15, 15.    [full-text]

36. Ren, W.; Xu, M.; Liang, S. H.; Xiang, H.; Tang, L.; Zhang, M.; Ding, D.; Li, X.; Zhang, H. & Hu, Y. "Discovery of a novel fluorescent probe for the sensitive detection of β-amyloid Deposits" Biosens. Bioelectron. 2015, 75, 136-141.   [full-text]

35. Liang, S. H.; Holland, J. P.; Stephenson, N. A.; Kassenbrock, A.; Rotstein, B. H.; Daignault, C. P.; Lewis, R.; Collier, L.; Hooker, J. M. & Vasdev, N. "PET Neuroimaging Studies of [18F]CABS13 in a Double Transgenic Mouse Model of Alzheimer’s Disease and Nonhuman Primates" ACS Chem. Neurosci. 2015, 6, 535-41. [full-text]

34. Liang, S. H.; Yokell, D. L.; Jackson, R. N.; Rice, P. A.; Livni, E.; Alagille, D.; Tamagnan, G.; Collier, T. L. & Vasdev, N., Synthesis of 3-[18F]fluoro-5-(2-pyridinylethynyl)benzonitrile ([18F]FPEB). In Radiochemical Syntheses, Vol 2:Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production, Scott, P. J. H., Ed. John Wiley & Sons, Inc.: Hoboken, New Jersey, 2015; Vol. 2, pp 41-51.

33. Rotstein, B. H.; Liang, S. H.; Belov, V. V.; Livni, E.; Levine, D. B.; Bonab, A. A.; Papisov, M. I.; Perlis, R. H. & Vasdev, N. "Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist" Molecules 2015, 20, 9550-9.    [full-text]

32. Rotstein, B. H.; Stephenson, N. A.; Vasdev, N. & Liang, S. H. "Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics" Nat. Commun. 2014, 5, 4365. [Open Access]

  •    Highlighted on Nat Commun Facebook page as "action shot";
  •    Selected by Chemical and Engineering News for "patentpicks" on October 26, 2015;
  •    also check my 'SCIDY' page.   

31. Liang, S. H.* & Vasdev, N.* "C(sp3)-18F Bond Formation by Transition-Metal-Based [18F]Fluorination" Angew. Chem. Int. Ed. 2014, 53, 11416-8. [full-text]

30. Kasahara, T.; Jang, Y. J.; Racicot, L.; Panagopoulos, D.; Liang, S. H. & Ciufolini, M. A. "Iodonium metathesis reactions" Angew. Chem. Int. Ed. 2014, 53, 9637-9. [link]    [full text]

29. Liang, S. H.; Yokell, D. L.; Jackson, R. N.; Rice, P. A.; Callahan, R.; Johnson, K. A.; Alagille, D.; Tamagnan, G.; Collier, T. L. & Vasdev, N. "Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging" Med. Chem. Commun. 2014, 5, 432-5. [full-text]

28. Liang, S. H.; Yokell, D. L.; Normandin, M. D.; Rice, P. A.; Jackson, R. N.; Shoup, T. M.; Brady, T. J.; El Fakhri, G.; Collier, T. L. & Vasdev, N. "First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807" Mol. Imaging 2014, 13, 1-5. [link]

  •    Featured as cover article;
  •    Highlighted on “SynthFlow” website!

27. Li, X.; Yang, C.; Wu, K.; Hu, Y.; Han, Y. & Liang, S. H. "A highly specific probe for sensing hydrogen sulfide in live cells based on copper-initiated fluorogen with aggregation-induced emission characteristics" Theranostics 2014, 4, 1233-8.  [full-text]

26. Holland, J. P.; Liang, S. H.; Rotstein, B. H.; Collier, T. L.; Stephenson, N. A.; Greguric, I. & Vasdev, N. "Alternative approaches for PET radiotracer development in Alzheimer's disease: imaging beyond plaque" J. Labelled. Comp. Radiopharm. 2014, 57, 323-31. [link]

25. Li, X.; Gong, Y.; Wu, K.; Liang, S. H.; Cao, J.; Yang, B.; Y., H. & Han, Y. "A highly sensitive and water soluble fluorescent probe for rapid detection of hydrogen sulfide in living cells" RSC Advances 2014, 4, 36106-9. [link]

24. Rotstein, B.; Liang, S. H. & Vasdev, N. "Clinical PET Research Realized by [11C]CO2-Fixation" Molecular Imaging Gateway 2014, 8.  [link]

23. Rotstein, B. H.; Hooker, J. M.; Woo, J.; Collier, T. L.; Brady, T. J.; Liang, S. H.* & Vasdev, N.* "Synthesis of [11C]Bexarotene by Cu-Mediated [11C]Carbon Dioxide Fixation and Preliminary PET Imaging" ACS Med. Chem. Lett. 2014, 5, 668-72. [full-text]

  •    Highlighted on journal cover!
  •    Featured on "The Cutting Edge of Chemistry - A Pharma Matters Report", Thomson Reuters, June 2014!

22. Rotstein, B. H.; Wey, H. Y.; Shoup, T. M.; Wilson, A. A.; Liang, S. H.; Hooker, J. M. & Vasdev, N. "PET Imaging of Fatty Acid Amide Hydrolase with [18F]DOPP in Nonhuman Primates" Mol. Pharm. 2014, 11, 3832-8. [full-text]

21. Liang, S. H.; Collier, T. L.; Rotstein, B. H.; Lewis, R.; Steck, M. & Vasdev, N. "Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds" Chem. Commun. 2013, 49, 8755-7. [link]

  •    Featured as cover article on Chem Commun;
  •    Highlighted on “SynthFlow” website!
  •    Rated by Organic & Biomolecular Chemistry as one of the latest exciting research in flow synthesis and continuous processing!

20. Rotstein, B. H.; Liang, S. H.; Holland, J. P.; Collier, T. L.; Hooker, J. M.; Wilson, A. A. & Vasdev, N. "11CO2 fixation: a renaissance in PET radiochemistry" Chem. Commun. 2013, 49, 5621-9.  [link] [full-text]

Selected publications (total 19 papers) from doctoral and postdoctoral work

Liang, H.; Hu, L.; Corey, E. J. "Di-tert-butylisobutylsilyl, another useful protecting group" Org. Lett. 2011, 13, 4120-3.

Liang, H.; Ciufolini, M. A. "Chiral hypervalent iodine reagents in asymmetric reactions" Angew. Chem. Int. Ed. 2011, 50, 11849-51.

Liang, H.; Ciufolini, M. A. "Oxidative Spirocyclization of Phenolic Sulfonamides: Scope and Applications" Chem. Eur. J. 2010, 16, 13262-70.

Liang, H.; Ciufolini, M. A. "Tandem Phenolic Oxidative Amidation−Intramolecular Diels−Alder Reaction: An Approach to the Himandrine Core" Org. Lett. 2010, 12, 1760-3.

Liang, H.; Ciufolini, M. A. "Improved Procedure for the Bimolecular Oxidative Amidation of Phenols" J. Org. Chem. 2008, 73, 4299-301.

Liang, H.; Schulé, A.; Vors, J.-P.; Ciufolini, M. A. "An Avenue to the Sordarin Core Adaptable to Analog Synthesis" Org. Lett. 2007, 9, 411922.