Publications in 2016

56. Yang, J.; Yang, J.; Liang, S. H.; Xu, Y.; Moore, A. & Ran. C.   "Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification" Sci. Rep. 2016, 6, 35613. [link]

H2O2

 

55. Yuan, Z.; Cheng, R.; Chen, P.; Liu, G. & Liang, S. H.   "Efficient Pathway for the Preparation of Aryl(isoquinoline)iodonium(III) Salts and Synthesis of Radiofluorinated Isoquinolines" Angew. Chem. Int. Ed. 2016, 55, 11882-11886. [link]

  •    Highlighted on "Xmol" news in Febrary issue 2017! 
  •    also check 'SCIDY' page.

 

Diaryliodonium

 

54. Rotstein, B. H.; Placzek, M. S.; Krishnan, H. S.; Pekosak, A.; Collier, T. L.; Wang, C.; Liang, S. H.; Burstein, E. S.; Hooker, J. M. & Vasdev, N.    "Preclinical PET neuroimaging of Preclinical PET neuroimaging of [11C]bexarotene" Molecular Imaging, 2016, 15, 1-5. [open access] [full-text]

 

53. Yuan, G.;  Jones, G. B.; Vasdev, N. & Liang, S. H.   "Radiosynthesis and preliminary PET evaluation of 18F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1, 2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors" Bioorg. Med. Chem. Lett. 2016, 26, 4857-4860. [link]

  •    also check 'SCIDY' page.

                                                             

 

52. Shi, H.; Braun, A.; Wang, L.; Liang, S. H.*; Vasdev, N* & Ritter, T.*   "Practical Synthesis of 18F-Difluoromethylarenes from Aryl (Pseudo) Halides" Angew. Chem. Int. Ed. 2016, 55, 10786-90.  [link]

CF2H

 

51. Liang, S. H.;  Chen, M. J.; Normandin, M. D.; Chang, J. S.; Chang, G. C.; Taylor, C. K.; Trapa, P.; Plummer, M. S.; Para, K. S.; Conn, E. L.; Lopresti-Morrow, L.; Lanyon, L. F.; Cook, J. M.; Richter, K. E. G.; Nolan, C. E.; Schachter, J. B.; Janat, F.; Che, Y.; Shanmugasundaram, V.; Lefker, B. A.; Enerson, B. E.; Livni, E.; Wang, L.; Guehl, N.; Patnaik, D.; Wagner, F. F.; Perlis, R.; Holson, E. B.; Haggarty, S. J.; El Fakhri, G.; Kurumbail, R. G. & Vasdev, N.  "Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) that Modulates Tau Phosphorylation in Brain: Translation for PET Neuroimaging" Angew. Chem. Int. Ed. 2016, 55, 9601-5.   [link]

  •    Featured as "Very Important Paper" (VIP) !

GSK3

 

50. Rotstein, B. H.; Liang, S. H.; Placzek, M. S.; Hooker, J. M.; Gee, A. D.; Dollé, F.; Wilson, A. A. & Vasdev, N.  "11C=O Bonds Made Easily for Positron Emission Tomography Radiopharmaceuticals" Chem. Soc. Rev. 2016, 45, 4708-26. [link]

 11C  O bonds made easily for positron emission tomography radiopharmaceuticals

 

49. Rotstein, B. H.; Wang, L.; Liu, R. Y.; Patteson, J.; Kwan, E. E.; Vasdev, N. & Liang, S. H.  "Mechanistic Studies and Radiofluorination of Structurally Diverse Pharmaceuticals with Spirocyclic Iodonium(III) Ylides" Chem. Sci. 2016, 7, 4407 - 4417.      [full-text]

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Mechanism

 

48. Wang, L.; Mori, W.; Cheng, R.; Yui, J.; Hatori, A.; Ma, L.; Zhang, Y.; Rotstein, B. H.; Fujinaga, M.; Shimoda, Y.; Yamasaki, T.; Xie, L.; Nagai, Y.; Minamimoto, T.; Higuchu, M.; Vasdev, N.; Zhang, M.-R. & Liang, S. H.    "Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase" Theranostics 2016, 6, 1145-1159.    [full-text]

MAGL-1

 

47. Rashidian, M.; Wang, L.; Eden, J. G.; Jacobsen, J.; Hossain, I.; Wang, Q.; Victoria, G. D.; Vasdev, N.; Ploegh, H. & Liang, S. H.    "Enzyme-Mediated Modification of Single Domain Antibodies for Imaging Modalities with different Characteristics" Angew. Chem. Int. Ed. 2016, 55, 528-533.   [full-text]

Nanobody

 

46. Wang, L.; Yui, J.; Wang, Q.; Zhang, Y.; Mori, W.; Shimoda, Y.; Fujinaga, M.; Kumata, K.; Yamasaki, T.; Hatori, A.; Rotstein, B. H.; Collier, T. L.; Ran, C.; Vasdev, N.; Zhang, M. -R. & Liang, S. H.    "Synthesis and Preliminary PET Imaging Studies of a FAAH Radiotracer ([11C]MPPO) Based on alpha-Ketoheterocyclic Scaffold" ACS Chem. Neurosci. 2016, 7, 109-18.   [full-text]

MPPO

 

45. Kassenbrock, A.; Vasdev, N. & Liang, S. H.    "Selected PET Radioligands for Ion Channel Linked Neuroreceptor Imaging: Focus on GABA, NMDA and nACh Receptors" Curr. Top. Med. Chem. 2016, 16, 1830-42.     [full-text]

PET ion channel