Publications in 2017

72. Collier, T. L.; Liang, S. H.; Mann, J. J.; Vasdev, N. and Kumar, J. S. D.  "Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors" Beilstein J. Org. Chem., 2017, 13, 2922-2927. DOI: 10.3762/bjoc.13.285 [full-text]

fempt

 

71. Bernard-Gauthier, V.; Legage, M.; Waengler, B.; Bailey, J. A.; Liang, S. H.; Perrin, D.; Vasdev, N. and Schirrmacher, R. "Recent advances in fluorine-18 radiochemistry: Focus on B-18F, Si-18F, Al-18F and C-18F radiofluorination via spirocyclic iodonium ylides" J Nucl. Med., 2017, asap. DOI: 10.2967/jnumed.117.197095

 

70. Zhang, X.; Kumata, K.; Yamasaki, T.; Cheng, R.; Hatori, A.; Ma, L.; Zhang, Y.; Wang, L.; Kang, H. J.; Sheffler, D. J.; Cosford, N. D. P.; Zhang, M-R & Liang, S. H. "Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide for Imaging of Metabotropic Glutamate Receptor 2" ACS Chem. NeuroSci. 2017, 8, 1937-1948. [link]  [full-text]

mglu2

 

69. Collier, T. L.; Maresca K. P.; Normandin, M. D.; Richardson, P.; McCarthy, T. J.; Liang, S. H.; Waterhouse, R. N. & Vasdev, N.  "Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET" Mol. Imaging, 2017, DOI: 10.1177/1536012117736669.  [link]

 

68. Bernard-Gauthier, V.; Collier, T. L.; Liang, S. H. & Vasdev, N. "Discovery of PET Radiopharmaceuticals at the Academia-Industry Interface"  Drug Discov. Today Technol., 2017, accepted. [link]

 

67. Ran, C.; Albrecht, D. S.; Bredella, M. A.; Yang, J.; Yang, J.; Liang, S. H.; Cypress, A. M.; Loggia, M. L.; Atassi, N. & Moore, A. "PET imaging of human brown adipose tissue with TSPO tracer [11C]PBR28" Mol. Imaging Biol., 2017, accepted. [link]

bat

 

66. Yuan, G.; Jankins, T. C.; Patrick, C. G.; Philbrook, P.; Sears, O.; Hatfield, S.; Sitkovsky, M.; Vasdev, N.; Liang, S. H.; Ondrechen, M. J.; Pollastri, M. P. & Jones, G. B.  "Fluorinated adenosine A2A receptor antagonists inspired by Preladenant as potential cancer immunotherapeutics" Int. J. Med. Chem., 2017, article ID 4852537. [link]

A2A

 

65. Krishnan, H.; Ma, L.; Vasdev, N. & Liang S. H. "18F-Labeling of Sensitive Biomolecules for Positron Emission Tomography" Chem. Eur. J. 2017, 23, 15553 - 15577. [link]  [full-text]

18F biomol

 

64. Yang, J.; Yang, J.; Wang, L.; Moore, A.; Liang, S. H. & Ran, C. "Synthesis-Free PET Imaging of Brown Adipose Tissue and TSPO via Combination of Disulfiram and 64CuCl2" Sci. Rep. 2017, 7, 8298. [link]

cudis

 

63. Dahl, K.; Collier, T. L.; Cheng, R.; Zhang, X.; Sadovski, O.; Liang, S. H. and Vasdev, N. "“In-Loop” [11C]CO2-Fixation: Prototype and Proof-of-Concept"   J. Labelled Comp. Radiopharm. 2017, 60, accepted. [link]

inloop

 

62. Collier, T. L.; Normandin, M. D.; Stephenson, N. A.; Livni, E.; Liang, S. H.; Wooten, D. W.; Esfahani, S. A.; Stabin, M. G.; Mahmood, U.; Chen, J.; Wang, W.; Maresca, K.; Waterhouse, R. N.; El Fakhri, G.; Richardson, P. & Vasdev, N. "Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib" Nat. Commun. 2017, accepted. [link]

  •       Check "SCIDY" page for novel 18F-labeling methodology.

ALK

 

61. Ma, L.; Placzek, M. S.; Hooker, J. M.; Vasdev, N. & Liang, S. H. "[11C]Cyanation of arylboronic acids in aqueous solutions" Chem. Commun. 2017, 53, 6597-6600. [link]  [full-text]

  •       Highlighted on "ChemViews Magazine" by Wiley-VCH and ChemPubSoc Europe in June 2017!
  •       Highlighted on "Synfacts" by Thieme August 2017!
  •       Highlighted on "Xmol" news in June issue 2017!

boron CN

 

60. Wang, L.; Cheng, R.; Fujinaga, M.; Yang, J.; Zhang, Y.; Hatori, A.; Kumata, K.; Yang, J.; Vasdev, N.; Du, Y.; Ran, C.; Zhang, M-R. & Liang, S. H.  "A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation" J. Med. Chem. 2017, 60, 5222-5227. [link]  [full-text]

  •       Highlighted on "Xmol" news in Ootober issue 2017!

   FDPA

 

59. Zheng, J.; Cheng, R.; Lin, J-H.; Yu, D-H.; Ma, L.; Jia, L.; Zhang, L.; Wang, L.; Xiao, J-C. & Liang, S. H. “An unconventional mechanistic insight on SCF3 formation from difluorocarbene: Preparation of 18F-labeled α-SCF3 carbonyl compounds” Angew. Chem. Int. Ed. 2017, in press. [link]  [full-text]

  •       Highlighted on "Atlas of Science" website in March 2017!
  •       Highlighted on "Xmol" news in April issue 2017!

 

 

58. Hu, K.; Patnaik, D.; Collier, T. L.; Lee, K. N.; Gao, H.; Swoyer, M. R.; Rotstein, B. H.; Krishnan, H. S.; Liang, S. H.; Wang, J.; Yan, Z.; Hooker, J. M.; Vasdev, N.; Haggarty, S. J. & Ngai, M-Y.  “Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3b Ligands for Positron Emission Tomography Imaging” ACS Med. Chem. Lett. 2017, in press. [link]

    

 

57. Yuan, G.; Wang, F.; Stephenson, N. A.; Wang, L.; Rotstein, B. H.; Vasdev, N.; Tang, P. & Liang, S. H.  "Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation" Chem. Commun. 2017, 53, 126-129. [link]

metal free CF2H method