Publications in 2019 (since Associate Professor)

95. Liang, S. H., Wang, L., Stephenson, N. A., Rotstein, B. H., and Vasdev, N. “Facile 18F Labeling of Non-activated Arenes via a Spirocyclic Iodonium(III) Ylide Method and its Application in the Synthesis of the mGluR5 PET Radiopharmaceutical [18F]FPEB” Nature Protocol, 2019, 14, 1530-1545. 

NP

 

94. Bernard-Gauthier, V., Mossine, A.V., Knight, A., Patnaik, D., Zhao, W., Cheng, C., Krishnan, H.S., Xuan, L.L., Chindavong, P.S., Reis, S.A., Chen, J.M., Shao, X., Stauff, J., Arteaga, J., Sherman, P.S., Salem, N., Bonsall, D., Amaral, B., Varlow, C., Wells, L., Martarello, L., Patel, S., Liang, S.H., Kurumbail, R.G., Haggarty, S.J., Scott, P.J.H. and Vasdev, N. "Structural Basis for Achieving GSK-3beta Inhibition with High Potency, Selectivity and Brain Exposure for PET Imaging and Drug Discovery" Journal of Medicinal Chemistry, 2019, ASAP, DOI: 10.1021/acs.jmedchem.9b01030.

GSK3

Highlighted as Journal Cover

  GSK3 cover

 

93. Chen, Z., Mori, W., Fu, H., Schafroth, M. A., Hatori, A., Shao, T., Zhang, G., Van, R. S., Zhang, Y., Hu, K., Fujinaga, M., Wang, L., Belov, V., Ogasawara, D., Giffenig, P., Deng, X., Rong, J., Yu, Q., Zhang, X., Papisov, M. I., Shao, Y., Collier, T. L., Ma, J.-A., Cravatt, B. F., Josephson, L., Zhang, M.-R., and Liang, S. H. "Design, Synthesis and Evaluation of 18F-labeled Monoacylglycerol lipase Inhibitors as Novel Positron Emission Tomography Probes" Journal of Medicinal Chemistry, 2019, 62, 8866-8872. DOI: 10.1021/acs.jmedchem.9b00936. 

Pf0571                 

Highlighted as Journal Cover

  MAGL cover

 

92. Nie, B., Wang, L., Hu, Y., Liang, S., Tan, Z., Chai, P., Tang, Y., Shang, J., Pan, Z., Zhao, X., Zhang, X., Gong, J., Zheng, C., Xu, H., Wey, H.-Y., Liang, S. H., and Shan, B. “A population stereotaxic positron emission tomography brain template for the macaque and its application to ischemic model” NeuroImage, 2019, ASAP, DOI: 10.1016/j.neuroimage.2019.116163

                                                     PET template                                      


91. Chen, Z., Shao, T., Gao, W., Fu, H., Collier, T. L., Rong, J., Deng, X., Yu, Q., Zhang, X., Davenport, A. T., Daunais, J. B., Wey, H. Y., Shao, Y., Josephson, L., Qiu, W., and Liang, S. H.  "Synthesis and Preliminary Evaluation of [11C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease" ChemMedChem, 2019, 14, 1580-1585.

                     GNE      

    Highlighted as Neuromedicine Hot Topics by ChemMedChem             

           hot topics

90. Zhang, B., Fraser, B. H., Klenner, M. A., Chen, Z., Liang, S. H., Massi, M., Robinson, A. J. and Pascali, G.  "[18F]Ethenesulfonyl fluoride as a novel radiofluoride relay reagent" Chemistry - A European Journal, 2019, accepted. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201900930

ESF

 

89. Chen, Z., Mori, W., Deng, X., Cheng, R., Ogasawara, D., Zhang, G., Schafroth, M. A., Dahl, K., Fu, H., Hatori, A., Shao, T., Zhang, Y., Yamasaki, T., Zhang, X., Rong, J., Yu, Q., Hu, K., Fujinaga, M., Xie, L., Kumata, K., Gou, Y., Chen, J., Gu, S., Bao, L., Wang, L., Collier, T. L., Vasdev, N., Shao, Y., Ma, J.-A., Cravatt, B. F., Fowler, C., Josephson, L., Zhang, M.-R. and Liang, S. H.  "Design, Synthesis and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a ‘Tail Switching’ Strategy on a Piperazinyl Azetidine Skeleton"  Journal of Medicinal Chemistry, 2019, 62, 3336-3353. DOI: 10.1021/acs.jmedchem.8b01778.  PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581563/

MAGL rever

 

88. Ran, C., Yang, J., Cheng, R., Fu, H., Yang, J., Kumar, M., Lu, J., Xu, Y., Liang, S. H., and Cui, M.  "Half-curcumin analogues as PET imaging probes for Amyloid beta species" Chemical Communications, 2019, ASAP, DOI: 10.1039/c8cc10166c.

curc

 

87. Shao, T., Josephson, L. and Liang, S. H. "PET/SPECT Molecular Probes for Diagnosis and Staging of Non-Alcoholic Fatty Liver Disease" Molecular Imaging, 2019, 18, 1-11. DOI: 10.1177/1536012119871455. 

NAFLD

 

86. Fu, H., Tang, W., Chen, Z., Belov, V., Zhang, G., Shao, T., Zhang, X., Yu, Q., Rong, J., Deng, X., Han, W., Myers, S., Giffenig, P., Wang, L., Josephson, L., Shao, Y., Davenport, A., Daunais, J., Papisov, M., Yuan, H., Li, Z., Traynelis, S. and Liang, S. H.  "Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist ([18F]N2B-0518) as PET Imaging Probe for GluN2B Subunit in the Brain"  ACS Chemical Neuroscience, 2019, 10, 2263-2275.   DOI: 10.1021/acschemneuro.8b00591.

N2B-0518

 

85. Deng, X., Hatori, A., Chen, Z., Kumata, K., Shao, T., Zhang, X., Yamasaki, T., Hu, K., Yu, Q., Ma, L., Wang, G., Wang, L., Shao, Y., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H.   "Synthesis and Preliminary Evaluation of 11C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4" ChemMedChem, 2019, 14, 303-309. DOI: 10.1002/cmdc.201800710.

M4_VU

  • This work is highlighted as Journal Cover and in the Neuromedicine Hot Topics by ChemMedChem.

M4

hot topics

 

84. Zhao, S., Wang, H., Sun, S., Guo, H., Chen, Z., Wang, J., Wang, L., Liang, S. H., and Wang, G.  "An efficient synthesis of 2-isoxazolines from α-haloketone oximes and dimethyl sulfonium salts" Tetrahedron Letters, 2019, ASAP, DOI:10.1016/j.tetlet.2018.12.062.