Publications in 2020

118. Zhang, X.; Zhang, Y.; Chen, Z.; Shao, T.; Van, R.; Kumata, K.; Deng, X.; Fu, H.; Yamasaki, T.; Rong, J.; Hu, K.; Hatori, A.; Xie, L.; Yu, Q.; Ye, W.; Xu, H.; Sheffler, D. J.; Cosford, N. D. P.; Shao, Y.; Tang, P.; Wang, L.; Zhang, M.-R. and Liang, S. H. "Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2"  Theranostics, 2020, 10, 11178-11196.

  • highlighted on Theranostics journal cover!

mGluR2 cover


117. Yamasaki, T.; Zhang, X.; Kumata, K.; Zhang, Y.; Deng, X.; Fujinaga, M.; Chen, Z.; Mori, W.; Hu, K; Wakizaka, H; Hatori, A.; Xie, L.; Ogawa, M.; Nengaki, N.; Van, R.; Shao, Y.; Sheffler, D. J.; Cosford, N. D. P.; Liang, S. H. and Zhang, M.-R. "Identification and Development of A New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2)"   Journal of Medicinal Chemistry, 2020, 63, 11469-11483.


  • highlighted on JMC journal cover!



116. Zhang, L.; Hu, K.; Shao, T.; Hou, L.; Zhang, S.; Ye, W.; Josephson, L.; Meyer, J. H.; Zhang, M.-R.; Vasdev, N.; Wang, J.; Xu, H.; Wang, L. and Liang, S. H.  "Recent developments on PET radiotracers for TSPO and their applications in neuroimaging"   Acta Pharmaceutica Sinica B, 2021, 11, 373-393.


115. Chen, Z.; Hou, L.; Gan, J.; Cai, Q.; Ye, W.; Chen, J.; Tan, Z.; Zheng, C.; Li, G.; Xu, H.; Fowler, C. J.; Liang, S. H. and Wang, L.  "Synthesis and Preliminary Evaluation of a Novel Positron Emission Tomography (PET) Ligand for Imaging Fatty Acid Amide Hydrolase (FAAH)"  Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127513. DOI:



114. Sun, J., Kumata, K., Chen, Z., Zhang, Y., Chen, J., Hatori, A., Fu, H., Rong, J., Deng, X., Yamasaki, T., Xie, L., Hu, K., Yu, Q., Shao, T., Collier, T. L., Josephson, L., Shao, Y., Du, Y., Wang, L., Xu, H., Zhang, M.-R. and Liang, S. H.  “Synthesis and Preliminary Evaluation of Novel 11C-Labeled GluN2B-selective NMDA Receptor Negative Allosteric Modulators” Acta Pharmacologica Sinica, 2020, DOI:10.1038/s41401-020-0456-9.



113. Brugarolas, P., Comstock, J., Dick, D.W., Ellmer, T., Engle, J.W., Lapi, S.E., Liang, S. H., Parent, E.E., Kishore, Pillarsetty N.V., Selivanova, S., Sun, X., Vavere, A., Scott, P.J.H., and Society of Nuclear Medicine and Molecular Imaging Radiopharmaceutical Sciences Council.    "Fifty Years of Radiopharmaceuticals" Journal of Nuclear Medicine Technology, 2020, 48 (Suppl 1), S34-39.  PMID: 32605944.

Abstract. To celebrate the 50th Anniversary of the founding of the SNMMI Technologists Section in 1970, the Radiopharmaceutical Sciences Council (RPSC) Board of Directors is pleased to contribute to this celebratory Supplement of the Journal of Nuclear Medicine Technology with a perspective highlighting major developments in the radiopharmaceutical sciences that have occurred in the last 50 years.



112. Varlow, C., Boileau, I., Wey, H-Y., Liang, S. H. and Vasdev, N.  "Classics in Neuroimaging: Imaging the Endocannabnoid Pathway with PET" ACS Chemical Neuroscience, 2020,    DOI:

  • highlighted on ACS CN journal cover!




111. Deng, X., Zhang, Y., Chen, Z., Kumata, K., Van, R., Rong, J., Shao, T., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Wey, H.-Y., Shao, Y., Josephson, L., Murtas, G., Pollegioni, L., Zhang, M.-R., and Liang, S. H.  “Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging” Bioorganic & Medicinal Chemistry Letters 2020, 30, 127326. Link:



110. Hu, K., Xie, L., Zhang, Y., Hanyu, M., Yang, Z., Nagatsu, K., Suzuki, H., Ouyang, J., Ji, X., Wei, J., Xu, H., Farokhzad, O. C., Liang, S. H.,* Wang, L.,* Tao, W.,* Zhang, M.-R.*   “Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy”  Nature Communications 2020, 11, 2778.



109. Deng, X., Zhang, Y., Rong, J., Kumata, K., Shao, T., Wang, G., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Shao, Y., Josephson, L., Sun, S., Zhang, M.-R., and Liang, S. H.  “Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4” Tetrahedron Letters, 2020, 61, 152060.  DOI:



108. Chen, Z., Chen, J., Mast, N., Rong, J., Deng, X., Shao, T., Fu, H., Yu, Q., Sun, J., Shao, Y., Josephson, L., Collier, T. L., Pikuleva, I. and Liang, S. H. “Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' 11CO2 fixation method” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127068. PubMed:



107. Xiao, Z., Wang, L., Wei, J., Ran, C., Liang, S. H., Shang, J., Chen, G. Y. and Zheng, C. “Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds” Chemical Communications, 2020, ASAP, DOI: 10.1039/d0cc00451k.

  • highlighted on Chem Commun journal cover!

photochem_mech             Photochem_xiao


106. Shao, T., Chen, Z., Belov, V., Wang, X., Rwema, S., Kumar, V., Fu, H., Deng, X., Rong, J., Yu, Q., Lang, L., Lin, W., Josephson, L., Samir, A., Chen, X., Chung, R. and Liang, S. H.  “[18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosisJournal of Hepatology, 2020, accepted.  PubMed:

  • highlighted on J Hep journal cover!





105. Liang, J., Huang, Y. Y., Zhou, Q., Cao, Y., Li, Z., Wu, D., Yu, S., Guo, L., Chen, Z., Huang, L., Liang, S. H., He, X., Wu, R., Luo H. B. "Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia” Journal of Medicinal Chemistry, 2020, 63, 3370-3380. PubMed:



104. Varlow, C., Murrell, E., Holland, J. P., Kassenbrock, A., Shannon, W., Liang, S. H., Vasdev, N. and Stephenson, N. A. “Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's DiseaseMolecules, 2020, 25, 982. DOI:



103. Lin, X. P., Xiao, Z. Z., Chen, T., Liang, S. H. and Guo, H. Q. “Glucose Metabolism on Tumor Plasticity, Diagnosis and Treatment” Frontiers in Oncology, 2020, 10, article 317. PMC:

glucose 2


102. Chen, J., Gan, J., Sun, J., Chen, Z., Fu, H., Rong, J., Deng, X., Shang, J., Gong, J., Collier, L., Wang, L., Xu, H. and Liang, S. H. “Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors” Tetrahedron Letters, 2020, 61, 151635. 



101. Yu, Q., Kumata, K., Li, H., Zhang, Y., Chen, Z., Zhang, X., Shao, T., Hatori, A., Yamasaki, T., Xie, L., Hu, K., Wang, G., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H. “Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126879.  



100. Wang, L., Yao, S., Tang, R., Zhu, H., Zhang, L., Gong, J., Chen, Q., Collier, T. L., Xu, H.,  and Liang, S. H.  “A concisely automated synthesis of TSPO radiotracer [18F]FDPA based on spirocyclic iodonium ylide (SCIDY) method and validation for human use” Journal of Labelled Compounds and Radiopharmaceuticals, 2020, accepted, DOI:

  • highlighted on JLCR journal cover!



99. Hu, K., Yang, Z.M., Zhang, L.L., Xie, L., Wang, L., Xu, H., Josephson, L., Liang, S.H. and Zhang, M.-R. “Boron agents for neutron capture therapy” Coordination Chemistry Reviews, 2020, 405, 213139. DOI:



98. Yu,  H., Zhao, W., Zhou, Y., Cheng, G-J., Sun, M., Wang, L., Yu, L., Ran, C. and Liang, S. H. "Salen-based Bifunctional Chemosensor for Copper (II) Ions: Inhibition of Copper-induced Amyloid-β Aggregation" Analytica Chimica Acta, 2020, 1097, 144-152.  DOI:



97. Lin, J-H., Deng, X., Xiao, J-C., and Liang, S. H.  "Recent advances in 18F-labeling of trifluoromethylthiolation", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2020, 649-665. DOI:

book chapter


96. Rong, J., Chen, Z., Vasdev, N. and Liang, S. H.  "Aryl-18F bond formation from nucleophilic [18F]fluoride", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2020, 617-648. DOI:

book chapter