Publications in 2020

118. Zhang, X.; Zhang, Y.; Chen, Z.; Shao, T.; Van, R.; Kumata, K.; Deng, X.; Fu, H.; Yamasaki, T.; Rong, J.; Hu, K.; Hatori, A.; Xie, L.; Yu, Q.; Ye, W.; Xu, H.; Sheffler, D. J.; Cosford, N. D. P.; Shao, Y.; Tang, P.; Wang, L.; Zhang, M.-R. and Liang, S. H. "Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2"  Theranostics, 2020, 10, 11178-11196.   https://pubmed.ncbi.nlm.nih.gov/33042277/

  • highlighted on Theranostics journal cover!

mGluR2 cover

 

117. Yamasaki, T.; Zhang, X.; Kumata, K.; Zhang, Y.; Deng, X.; Fujinaga, M.; Chen, Z.; Mori, W.; Hu, K; Wakizaka, H; Hatori, A.; Xie, L.; Ogawa, M.; Nengaki, N.; Van, R.; Shao, Y.; Sheffler, D. J.; Cosford, N. D. P.; Liang, S. H. and Zhang, M.-R. "Identification and Development of A New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2)"   Journal of Medicinal Chemistry, 2020, 63, 11469-11483.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892210/

 

  • highlighted on JMC journal cover!

mGluR2_JMC

 

116. Zhang, L.; Hu, K.; Shao, T.; Hou, L.; Zhang, S.; Ye, W.; Josephson, L.; Meyer, J. H.; Zhang, M.-R.; Vasdev, N.; Wang, J.; Xu, H.; Wang, L. and Liang, S. H.  "Recent developments on PET radiotracers for TSPO and their applications in neuroimaging"   Acta Pharmaceutica Sinica B, 2021, 11, 373-393.    https://pubmed.ncbi.nlm.nih.gov/33643818/

tspo

115. Chen, Z.; Hou, L.; Gan, J.; Cai, Q.; Ye, W.; Chen, J.; Tan, Z.; Zheng, C.; Li, G.; Xu, H.; Fowler, C. J.; Liang, S. H. and Wang, L.  "Synthesis and Preliminary Evaluation of a Novel Positron Emission Tomography (PET) Ligand for Imaging Fatty Acid Amide Hydrolase (FAAH)"  Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127513. DOI: https://doi.org/10.1016/j.bmcl.2020.127513

dup18

 

114. Sun, J., Kumata, K., Chen, Z., Zhang, Y., Chen, J., Hatori, A., Fu, H., Rong, J., Deng, X., Yamasaki, T., Xie, L., Hu, K., Yu, Q., Shao, T., Collier, T. L., Josephson, L., Shao, Y., Du, Y., Wang, L., Xu, H., Zhang, M.-R. and Liang, S. H.  “Synthesis and Preliminary Evaluation of Novel 11C-Labeled GluN2B-selective NMDA Receptor Negative Allosteric Modulators” Acta Pharmacologica Sinica, 2020, DOI:10.1038/s41401-020-0456-9.

NR2B

 

113. Brugarolas, P., Comstock, J., Dick, D.W., Ellmer, T., Engle, J.W., Lapi, S.E., Liang, S. H., Parent, E.E., Kishore, Pillarsetty N.V., Selivanova, S., Sun, X., Vavere, A., Scott, P.J.H., and Society of Nuclear Medicine and Molecular Imaging Radiopharmaceutical Sciences Council.    "Fifty Years of Radiopharmaceuticals" Journal of Nuclear Medicine Technology, 2020, 48 (Suppl 1), S34-39.  PMID: 32605944.

Abstract. To celebrate the 50th Anniversary of the founding of the SNMMI Technologists Section in 1970, the Radiopharmaceutical Sciences Council (RPSC) Board of Directors is pleased to contribute to this celebratory Supplement of the Journal of Nuclear Medicine Technology with a perspective highlighting major developments in the radiopharmaceutical sciences that have occurred in the last 50 years.

RP50

 

112. Varlow, C., Boileau, I., Wey, H-Y., Liang, S. H. and Vasdev, N.  "Classics in Neuroimaging: Imaging the Endocannabnoid Pathway with PET" ACS Chemical Neuroscience, 2020,    DOI: https://dx.doi.org/10.1021/acschemneuro.0c00305.

  • highlighted on ACS CN journal cover!

eCB_viewpoint

ecb_viewpoint_cover

 

111. Deng, X., Zhang, Y., Chen, Z., Kumata, K., Van, R., Rong, J., Shao, T., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Wey, H.-Y., Shao, Y., Josephson, L., Murtas, G., Pollegioni, L., Zhang, M.-R., and Liang, S. H.  “Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging” Bioorganic & Medicinal Chemistry Letters 2020, 30, 127326. Link: https://www.sciencedirect.com/science/article/abs/pii/S0960894X20304376

DAO

 

110. Hu, K., Xie, L., Zhang, Y., Hanyu, M., Yang, Z., Nagatsu, K., Suzuki, H., Ouyang, J., Ji, X., Wei, J., Xu, H., Farokhzad, O. C., Liang, S. H.,* Wang, L.,* Tao, W.,* Zhang, M.-R.*   “Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy”  Nature Communications 2020, 11, 2778.

BP

 

109. Deng, X., Zhang, Y., Rong, J., Kumata, K., Shao, T., Wang, G., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Shao, Y., Josephson, L., Sun, S., Zhang, M.-R., and Liang, S. H.  “Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4” Tetrahedron Letters, 2020, 61, 152060.  DOI: https://doi.org/10.1016/j.tetlet.2020.152060

M4

 

108. Chen, Z., Chen, J., Mast, N., Rong, J., Deng, X., Shao, T., Fu, H., Yu, Q., Sun, J., Shao, Y., Josephson, L., Collier, T. L., Pikuleva, I. and Liang, S. H. “Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' 11CO2 fixation method” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127068. PubMed: https://pubmed.ncbi.nlm.nih.gov/32178974/

CYP46A1

 

107. Xiao, Z., Wang, L., Wei, J., Ran, C., Liang, S. H., Shang, J., Chen, G. Y. and Zheng, C. “Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds” Chemical Communications, 2020, ASAP, DOI: 10.1039/d0cc00451k.

  • highlighted on Chem Commun journal cover!

photochem_mech             Photochem_xiao

 

106. Shao, T., Chen, Z., Belov, V., Wang, X., Rwema, S., Kumar, V., Fu, H., Deng, X., Rong, J., Yu, Q., Lang, L., Lin, W., Josephson, L., Samir, A., Chen, X., Chung, R. and Liang, S. H.  “[18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosisJournal of Hepatology, 2020, accepted.  PubMed: https://pubmed.ncbi.nlm.nih.gov/32145257/

  • highlighted on J Hep journal cover!

             Alfatide

avb3_b

avb3_cover

 

105. Liang, J., Huang, Y. Y., Zhou, Q., Cao, Y., Li, Z., Wu, D., Yu, S., Guo, L., Chen, Z., Huang, L., Liang, S. H., He, X., Wu, R., Luo H. B. "Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia” Journal of Medicinal Chemistry, 2020, 63, 3370-3380. PubMed: https://pubmed.ncbi.nlm.nih.gov/32115956/

PDE4

 

104. Varlow, C., Murrell, E., Holland, J. P., Kassenbrock, A., Shannon, W., Liang, S. H., Vasdev, N. and Stephenson, N. A. “Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's DiseaseMolecules, 2020, 25, 982. DOI: https://doi.org/10.3390/molecules25040982

FPEB AD

 

103. Lin, X. P., Xiao, Z. Z., Chen, T., Liang, S. H. and Guo, H. Q. “Glucose Metabolism on Tumor Plasticity, Diagnosis and Treatment” Frontiers in Oncology, 2020, 10, article 317. PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069415/

glucose 2

 

102. Chen, J., Gan, J., Sun, J., Chen, Z., Fu, H., Rong, J., Deng, X., Shang, J., Gong, J., Collier, L., Wang, L., Xu, H. and Liang, S. H. “Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors” Tetrahedron Letters, 2020, 61, 151635.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062035/ 

AMPA 1b

 

101. Yu, Q., Kumata, K., Li, H., Zhang, Y., Chen, Z., Zhang, X., Shao, T., Hatori, A., Yamasaki, T., Xie, L., Hu, K., Wang, G., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H. “Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126879.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045276/  

TARP

 

100. Wang, L., Yao, S., Tang, R., Zhu, H., Zhang, L., Gong, J., Chen, Q., Collier, T. L., Xu, H.,  and Liang, S. H.  “A concisely automated synthesis of TSPO radiotracer [18F]FDPA based on spirocyclic iodonium ylide (SCIDY) method and validation for human use” Journal of Labelled Compounds and Radiopharmaceuticals, 2020, accepted, DOI: https://doi.org/10.1002/jlcr.3824

  • highlighted on JLCR journal cover!

   FDPA

FDPA_JLCR

99. Hu, K., Yang, Z.M., Zhang, L.L., Xie, L., Wang, L., Xu, H., Josephson, L., Liang, S.H. and Zhang, M.-R. “Boron agents for neutron capture therapy” Coordination Chemistry Reviews, 2020, 405, 213139. DOI: https://doi.org/10.1016/j.ccr.2019.213139

boron

 

98. Yu,  H., Zhao, W., Zhou, Y., Cheng, G-J., Sun, M., Wang, L., Yu, L., Ran, C. and Liang, S. H. "Salen-based Bifunctional Chemosensor for Copper (II) Ions: Inhibition of Copper-induced Amyloid-β Aggregation" Analytica Chimica Acta, 2020, 1097, 144-152.  DOI: https://doi.org/10.1016/j.aca.2019.10.072.

pimi

 

97. Lin, J-H., Deng, X., Xiao, J-C., and Liang, S. H.  "Recent advances in 18F-labeling of trifluoromethylthiolation", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2020, 649-665. DOI: https://doi.org/10.1142/9781786347336_0014

book chapter

 

96. Rong, J., Chen, Z., Vasdev, N. and Liang, S. H.  "Aryl-18F bond formation from nucleophilic [18F]fluoride", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2020, 617-648. DOI: https://doi.org/10.1142/9781786347336_0013

book chapter