Publications in 2020

110. Hu et al., "Marriage of black phosphorus and copper ions: Developing novel photothermal agents for PET-guided combination cancer therapy" Nature Communications, 2020, just accepted.

BP

 

109. Deng, X., Zhang, Y., Rong, J., Kumata, K., Shao, T., Wang, G., Hatori, A., Mori, W., Yu, Q., Hu, K., Fujinaga, M., Shao, Y., Josephson, L., Sun, S., Zhang, M.-R., and Liang, S. H.  “Synthesis and preliminary evaluation of 18F-labeled 1-(6,7-dimethyl-4-(methylamino)-1,3-dihydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-2-(trans-2-(6-fluoropyridin-3-yl)cyclopropyl)ethan-1-one for imaging muscarinic acetylcholine receptor subtype 4” Tetrahedron Letters, 2020, 61, 152060.  DOI: https://doi.org/10.1016/j.tetlet.2020.152060

M4

 

108. Chen, Z., Chen, J., Mast, N., Rong, J., Deng, X., Shao, T., Fu, H., Yu, Q., Sun, J., Shao, Y., Josephson, L., Collier, T. L., Pikuleva, I. and Liang, S. H. “Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' 11CO2 fixation method” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127068. PubMed: https://pubmed.ncbi.nlm.nih.gov/32178974/

CYP46A1

 

107. Xiao, Z., Wang, L., Wei, J., Ran, C., Liang, S. H., Shang, J., Chen, G. Y. and Zheng, C. “Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds” Chemical Communications, 2020, ASAP, DOI: 10.1039/d0cc00451k.

photochem_mech             Photochem_xiao

 

106. Shao, T., Chen, Z., Belov, V., Wang, X., Rwema, S., Kumar, V., Fu, H., Deng, X., Rong, J., Yu, Q., Lang, L., Lin, W., Josephson, L., Samir, A., Chen, X., Chung, R. and Liang, S. H.  “[18F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosisJournal of Hepatology, 2020, accepted.  PubMed: https://pubmed.ncbi.nlm.nih.gov/32145257/

             Alfatide

avb3_b

 

105. Liang, J., Huang, Y. Y., Zhou, Q., Cao, Y., Li, Z., Wu, D., Yu, S., Guo, L., Chen, Z., Huang, L., Liang, S. H., He, X., Wu, R., Luo H. B. "Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia” Journal of Medicinal Chemistry, 2020, 63, 3370-3380. PubMed: https://pubmed.ncbi.nlm.nih.gov/32115956/

PDE4

 

104. Varlow, C., Murrell, E., Holland, J. P., Kassenbrock, A., Shannon, W., Liang, S. H., Vasdev, N. and Stephenson, N. A. “Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer's DiseaseMolecules, 2020, 25, 982. DOI: https://doi.org/10.3390/molecules25040982

FPEB AD

 

103. Lin, X. P., Xiao, Z. Z., Chen, T., Liang, S. H. and Guo, H. Q. “Glucose Metabolism on Tumor Plasticity, Diagnosis and Treatment” Frontiers in Oncology, 2020, 10, article 317. PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069415/

glucose 2

 

102. Chen, J., Gan, J., Sun, J., Chen, Z., Fu, H., Rong, J., Deng, X., Shang, J., Gong, J., Collier, L., Wang, L., Xu, H. and Liang, S. H. “Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors” Tetrahedron Letters, 2020, 61, 151635.  DOI: https://doi.org/10.1016/j.tetlet.2020.151635.

AMPA 1b

 

101. Yu, Q., Kumata, K., Li, H., Zhang, Y., Chen, Z., Zhang, X., Shao, T., Hatori, A., Yamasaki, T., Xie, L., Hu, K., Wang, G., Josephson, L., Sun, S., Zhang, M-R. and Liang, S. H. “Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET” Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126879. DOI: https://doi.org/10.1016/j.bmcl.2019.126879

TARP

 

100. Wang, L., Yao, S., Tang, R., Zhu, H., Zhang, L., Gong, J., Chen, Q., Collier, T. L., Xu, H.,  and Liang, S. H.  “A concisely automated synthesis of TSPO radiotracer [18F]FDPA based on spirocyclic iodonium ylide (SCIDY) method and validation for human use” Journal of Labelled Compounds and Radiopharmaceuticals, 2020, accepted, DOI: https://doi.org/10.1002/jlcr.3824

   FDPA

FDPA_JLCR

99. Hu, K., Yang, Z.M., Zhang, L.L., Xie, L., Wang, L., Xu, H., Josephson, L., Liang, S.H. and Zhang, M.-R. “Boron agents for neutron capture therapy” Coordination Chemistry Reviews, 2020, 405, 213139. DOI: https://doi.org/10.1016/j.ccr.2019.213139

boron

 

98. Yu,  H., Zhao, W., Zhou, Y., Cheng, G-J., Sun, M., Wang, L., Yu, L., Ran, C. and Liang, S. H. "Salen-based Bifunctional Chemosensor for Copper (II) Ions: Inhibition of Copper-induced Amyloid-β Aggregation" Analytica Chimica Acta, 2020, 1097, 144-152.  DOI: https://doi.org/10.1016/j.aca.2019.10.072.

pimi

 

97. Lin, J-H., Deng, X., Xiao, J-C., and Liang, S. H.  "Recent advances in 18F-labeling of trifluoromethylthiolation", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2020, 649-665. DOI: https://doi.org/10.1142/9781786347336_0014

book chapter

 

96. Rong, J., Chen, Z., Vasdev, N. and Liang, S. H.  "Aryl-18F bond formation from nucleophilic [18F]fluoride", in Frontiers of Organofluorine Chemistry, World Scientific, Hackensack, NJ, 2020, 617-648. DOI: https://doi.org/10.1142/9781786347336_0013

book chapter