Publications in 2021

133. Chen, Z.; Haider, A.; Chen, J.; Xiao, Z.; Gobbi, L.; Honer, M.; Grether, U.; Arnold, S.; Josephson, L. and Liang, S. H. "The repertoire of small molecule PET probes for neuroinflammation imaging: challenges and opportunities beyond TSPO", Journal of Medicinal Chemistry, 2021, accepted.

neuroinflammation

 

132. Deng, X.; Salgado-Polo, F.; Shao, T.; Xiao, Z.; Van, R.; Chen, J.; Rong, J.; Haider, A.; Shao, Y.; Josephson, L.; Perrakis, A. and Liang, S. H. "Imaging autotaxin in vivo with 18F-labeled positron emission tomography ligands", Journal of Medicinal Chemistry, 2021, 64, 15053-15068. Link: https://pubmed.ncbi.nlm.nih.gov/34662125/

  • highlighted on JMC journal cover!

ATX

ATX_cover

 

131. Rong, J.; Mori, W.; Xia, X.; Schafroth, M. A.; Zhao, C.; Van, R. S.; Yamasaki, T.; Chen, J.; Xiao, Z.; Haider, A.; Ogasawara, D.; Hiraishi, A.; Shao, T.; Zhang, Y.; Chen, Z.; Pang, F.; Hu, K.; Xie, L.; Fujinaga, M.; Kumata, K.; Gou, Y.; Fang, Y.; Gu, S.; Wei, H.; Bao, L.; Xu, H.; Collier, T. L.; Shao, Y.; Carson, R. E.; Cravatt,B. F.; Wang,L.; Zhang, M.-R. and Liang S. H. “Novel reversible-binding PET ligands for imaging monoacylglycerol lipase based on piperazinyl azetidine scaffold”, Journal of Medicinal Chemistry, 2021, 64, 14283-14298. Link: https://pubmed.ncbi.nlm.nih.gov/34569803/ 

  • highlighted on JMC journal cover!

MAGL02-14

MAGL JMC


130. Xiao, Z.; Wei, H.; Xu, Y.; Haider, A.; Wei, J.; Yuan, S.; Rong, J.; Zhao, C.; Li, G.; Zhang, W.; Chen, H.; Li, Y.; Zhang, L.; Sun, J.; Zhang, S.; Luo, H.-B.; Yan, S.; Cai, Q.; Hou, L.; Che, C.; Liang, S. H. and Wang, L. "Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination", Acta Pharmaceutica Sinica B, 2021, ASAP. Link: https://www.sciencedirect.com/science/article/pii/S2211383521004470

PDE10A

129. Haider, A; Xiao, Z; Xia, X; Chen, J; Van, RS; Kuang, S; Zhao, C; Rong, J; Shao, T; Ramesh, P; Aravind, A; Shao, Y; Ran, C; Young, LJ; Liang, SH. "Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging". Pharmacological Research, 2021, accepted, Link: https://doi.org/10.1016/j.phrs.2021.105886

V1A

 

128. Yamasaki, T; Hatori, A; Zhang, Y; Mori, W; Kurihara, Y; Ogawa, M; Wakizaka, H; Rong, J; Wang, L; Liang, S. H. and Zhang, M-R.  "Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study", Theranostics, 2021, 11, 9492–9502. Link: https://pubmed.ncbi.nlm.nih.gov/34646382/

MAGL

KML29_MCAO

 

127. Shao, T.; Chen, Z.; Rong, J.; Belov, V.; Chen, J.; Jeyarajab, A.; Deng, X.; Fu, H.; Yu, Q.; Rwema, S.; Lin, W.; Papisov, M.; Josephson, L.; Chung, R. and Liang, S.H.  "[18F]-MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models",  Acta Pharmaceutica Sinica B, 2021, accepted, Link: https://authors.elsevier.com/sd/article/S2211-3835(21)00256-2

MALG liver

 

126. Sun, J.; Xiao, Z.; Haider, A.; Gebhard, C.; Xu, H.; Luo, H. B.; Zhang, H. T.; Josephson, L.; Wang, L. and Liang, S. H. "Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery",  Journal of Medicinal Chemistry, 2021, 64, 7083-7109.    DOI: https://pubmed.ncbi.nlm.nih.gov/34042442/ 

PDE

 

125. Deppen, J. N.; Ginn, S. C.; Kim, N. H.; Wang, L.; Voll, R.J.; Liang, S. H.; Goodman, M. M.; Oshinski, J. N. and Levit, R. D. "A Swine Hind Limb Ischemia Model Useful for Testing Peripheral Artery Disease Therapeutics", Journal of Cardiovascular Translational Research, 2021, accepted. DOI: https://link.springer.com/article/10.1007/s12265-021-10134-8

swine model

 

124. Sun, J.; Chen, J.; Kumata, K.; Xiao, Z.; Rong, J.; Haider, A.; Shao, T.; Wang, L.; Xu, H.; Zhang, M.-R. and Liang, S. H.  "Imaging the trace amine-associated receptor 1 by positron emission tomography", Tetrahedron Letters, 2021, 153007.  https://www.sciencedirect.com/science/article/abs/pii/S0040403921002033 

taar1

 

123. Zhang, X.; Xiao, Z.; Kumata, K.; Yamasaki, T.; Josephson, L.; Zhang, M.-R.; Wang, L. and Liang, S. H.  "Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand. In Metabotropic Glutamate Receptor Technologies", Olive, M. F.; Burrows, B. T.; Leyrer-Jackson, J. M., Eds. Springer US: New York, NY, 2021; pp 23-37.   https://link.springer.com/protocol/10.1007%2F978-1-0716-1107-4_2 

mGlu2 book chapter

 

122. Knight, A.C.; Varlow, C.; Zi, T.; Liang, S.H.; Josephson, L.; Schmidt, K.; Patel, S. and Vasdev, N. "In Vitro Evaluation of [3H]CPPC as a Tool Radioligand for CSF-1R" ACS Chemical Neuroscience, 2021, accepted. https://pubmed.ncbi.nlm.nih.gov/33667059/

cppc

 

121. Rong, J.; Haider, A. and Liang, S. H. "Precision Radiochemistry for Fluorine-18 Labeling of PET Tracers". In Organofluorine Chemistry: Synthesis, Modeling, and Applications, 2021; pp 397-425.  Editor(s): Kálmán Szabó & Nicklas Selander. WILEY‐VCH GmbH, Boschstr.  https://onlinelibrary.wiley.com/doi/book/10.1002/9783527825158 

book chapter 2021

 

120. Chen, Z.; Mori, W.; Rong, J.; Schafroth, M. A.; Shao, T.; Van, R. S.; Ogasawara, D.; Yamasaki, T.; Hiraishi, A.;  Hatori, A.; Chen, J.; Zhang, Y.; Hu, K.; Fujinaga, M.; Sun, J.; Yu, Q.; Collier, T. L.; Shao, Y.; Cravatt, B. F.; Josephson, L.; Zhang, M-R. and Liang, S. H. "Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping" Acta Pharmaceutica Sinica B, 2021, accepted.  DOI: https://www.sciencedirect.com/science/article/pii/S2211383521000381

MAGL_pyridine

 

119. Hou, L.; Rong, J.; Haider, A.; Ogasawara, D.; Varlow, C.; Schafroth, M. A.; Mu, L.; Gan, J.; Xu, H.; Fowler, C. J.; Zhang, M-R.; Vasdev, N.; Ametamey, S.; Cravatt, B. F.; Wang, L. and Liang, S. H.  "Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development" Journal of Medicinal Chemistry, 2021, accepted.  DOI: https://pubmed.ncbi.nlm.nih.gov/33379862/ 

eCB