Resource Page

For group member only, please add shared dropbox folder for internal resources and training.  Email Steven for invite!

 

PET in Drug Discovery

Lee, C. M.; Farde, L. "Using positron emission tomography to facilitate CNS drug development" Trends Pharmacol Sci 2006, 27, 310-6.

Matthews, P. M.; Rabiner, E. A.; Passchier, J.; Gunn, R. N. "Positron emission tomography molecular imaging for drug development" Br J Clin Pharmacol 2012, 73, 175-86.

Piel, M.; Vernaleken, I.; Rösch, F. "Positron Emission Tomography in CNS Drug Discovery and Drug Monitoring" J. Med. Chem. 2014, 57, 9232-9258.

PET Tracer Development

Pike, V. W. "PET radiotracers: crossing the blood-brain barrier and surviving metabolism" Trends Pharmacol Sci 2009, 30, 431-40.

Pike, V. W. "Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging" Curr Med Chem 2016, 23, 1818-1869.

Brain Penetration

Di, L.; Rong, H.; Feng, B. "Demystifying brain penetration in central nervous system drug discovery" J. Med. Chem. 2013, 56, 2-12. [link]