Publications

(*denotes co-first author)

2016
17. Gujral, T.S., and Kirschner, M.W. Cell-cell contact regulates drug sensitivity. Manuscript.
 
2014
16. Gujral, T.S., Chan, M., Peshkin, L., Sorger, P.K., Kirschner, M.W. and MacBeath, G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159 (4), 844–856 (2014). Pubmed. 

15. Gujral, T.S*., Peshkin, L*., and Kirschner M.W. Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A. 111 (13) 5048-5053 (2014). Pubmed. 

2013
14. Gujral, T.S*., Karp, E.S*., Chan, M., Chang, B. and MacBeath, G. Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions. Chemistry & Biology 20, 816-27 (2013). Pubmed

13. Hyndman, B.D*., Gujral, T.S*., Krieger, J.R., Cockburn, J.G. and Mulligan, L.M. Multiple functional effects of RET kinase domain sequence variants in Hirschsprung disease. Human mutation 34, 132-42 (2013). Pubmed

2012
12. Gujral, T.S., Karp., R, Finski,A., Chan, M., MacBeath, G and Sorger, P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene (2012). Pubmed

11. Luckert, K*., Gujral, T.S.*, Chan, M., Joos, T.O., Sorger, P., MacBeath, G., and Potz, O.A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Science Signaling 5, pl1 (2012). Pubmed

2011
10. Chang, B.H*., Gujral, T.S*.,  Karp, E.S., BuKhalid, R., Grantcharova, V.P., and MacBeath, G. A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions. Chemistry & Biology 18, 1143-52 (2011). Pubmed

2010
9. Cockburn, J.G., Richardson, D.S., Gujral, T.S. & Mulligan, L.M. RET-mediated cell adhesion and migration require multiple integrin subunits. J Clin Endocrinol Metab 95, E342-6 (2010). Pubmed.

8. Shalek, A.K., Robinson,  J.T., Karp, E., Seok Lee, J., Ahn, D., Yoon, M., Sutton, A.,  Jorgolli, M.,  Gertner, R., Gujral, T.S., MacBeath, G., Yang, E., and Park, H. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proc Natl Acad Sci U S A 107, 1870-5 (2010). Pubmed.

7. Gujral, T.S. & Macbeath, G. A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. PLoS One 5, e10024 (2010). Pubmed.

2009
6. Richardson, D.S., Gujral, T.S., Peng, S., Asa, S.L. & Mulligan, L.M. Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins. Cancer Research 69, 4861-9 (2009). Pubmed.

5. Gujral, T.S. & Macbeath, G. Emerging miniaturized proteomic technologies to study cell signaling in clinical samples. Science Signaling 2, pe65 (2009).Pubmed.

2008
4. Gujral, T.S., Van Veelen, W., Richardson, D., Myers, S, Meens, J., Acton, D., Duñach, M, Elliott, B.E., and Mulligan, L. M. A novel RET kinase-beta-catenin signaling pathway contributes to tumorigenesis in thyroid carcinoma. Cancer Research 68, 1338-46 (2008). Pubmed.

2007
3. Lai, A.Z., Gujral, T.S. & Mulligan, L.M. RET signaling in endocrine tumors: delving deeper into molecular mechanisms. Endocr Pathol 18, 57-67 (2007). Pubmed.

2006
2. Gujral, T.S., Singh, V.K., Jia, Z. & Mulligan, L.M. Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2B. Cancer Research 66, 10741-9 (2006). Pubmed.

1. Gujral, T.S. & Mulligan, L.M. Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2. Ann N Y Acad Sci 1073, 234-40 (2006). Pubmed.