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Tim Anderson, Ashley Valle Arevalo, Clarissa J Nobile, and Aaron D Hernday. 2018. “The Roles of Chromatin Accessibility in Regulating the White-Opaque Phenotypic Switch - sticky.” J Fungi (Basel), 7, 1.
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Abstract
Candida albicans, a diploid polymorphic fungus, has evolved a unique heritable epigenetic program that enables reversible phenotypic switching between two cell types, referred to as "white" and "opaque". These cell types are established and maintained by distinct transcriptional programs that lead to differences in metabolic preferences, mating competencies, cellular morphologies, responses to environmental signals, interactions with the host innate immune system, and expression of approximately 20% of genes in the genome. Transcription factors (defined as sequence specific DNA-binding proteins) that regulate the establishment and heritable maintenance of the white and opaque cell types have been a primary focus of investigation in the field; however, other factors that impact chromatin accessibility, such as histone modifying enzymes, chromatin remodelers, and histone chaperone complexes, also modulate the dynamics of the white-opaque switch and have been much less studied to date. Overall, the white-opaque switch represents an attractive and relatively "simple" model system for understanding the logic and regulatory mechanisms by which heritable cell fate decisions are determined in higher eukaryotes. Here we review recent discoveries on the roles of chromatin accessibility in regulating the C. albicans white-opaque phenotypic switch.
2021 Jul 02

Future 1

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Myst III: Exile est un jeu vidéo d'aventure à la première personne qui fait suite à Myst et à Riven. Contrairement aux précédents épisodes, ce troisième opus n'a pas été développé par Cyan Worlds mais par Presto Studios. Le jeu, édité par Ubisoft, est tout d'abord sorti sur PC en 2001, puis sur PlayStation 2 et Xbox fin 2002. Le joueur prend le rôle d'un ami d'Atrus. Membre de la race D'ni, Atrus peut créer des liaisons vers d'autres mondes, appelés Âges, en écrivant des livres descriptifs. Dans Exile, Atrus a écrit un Âge pour que les D'ni puissent... Read more about Future 1
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