P.S. Thiagarajan received his B.Tech (Electrical Engineering) from the Indian Institute of Technology, Madras (1970) and his PhD (Computer Science) from Rice University, Houston, Texas (1973). Starting with a post-doctoral stint with Jack Dennis at MIT (1973-75) he has held permanent positions at the Gesellschaft fuer Mathematik and Datenverarbeiting (GMD), St.Augustin, West Germany (1975-83), Aarhus University, Denmark (1983-86) and the Institute of Mathematical Sciences, Chennai, India (1986-89). In 1989 he co-founded -with the algebraic geometer Prof. C. S. Seshadri- the Chennai Mathematical Institute which is now considered to be the best institution in India providing undergraduate education in Mathematics (with streams in pure mathematics, computer science and physics). From 2001 he was a professor at the National University of Singapore until reaching the mandatory retirement age in 2015. Since then he has been a visiting professor at LSP.
P.S. Thiagarajan has pursued a variety of topics in computer science. Starting from a long innings in concurrency theory (with a focus on Petri nets and related models), he has studied temporal logics, formal verification techniques based on model checking, real time embedded systems as well as stochastic and hybrid dynamical systems. Bowled over by the incredible range and complexity of the dynamics exhibited by biological processes, he turned to computational systems biology around 10 years ago. Working in collaboration with biologists he has developed probabilistic approximation techniques for analysing high dimensional systems of ordinary differential equations (that arise as models of signalling pathways) as well hybrid system models of bio-pathways.
At the Laboratory of Systems Pharmacolgy (LSP) he started studying distributed stochastic dynamics with an eye towards modelling clonal evolutionary dynamics in cancer biology settings. His current focus is the compact representation and analysis of large collections of graphs. It turns out that a number of datasets that have been or being generated by LSP researchers can be brought under this regime.
Selected publications :
Bing Liu, Qian Liu, Lei Yang, Sucheendra K. Palaniappan, Ivet Bahar, P.S. Thiagarajan, Ding Jeak Ling: Innate immune memory and homeostasis may be conferred through crosstalk between TLR3 and TLRpathways, Science Signaling, 9(436) (2016)
Junjie Wang, Lisa Tucker-Kellog, Inn Chuan Ng, Ruirui Jia, P.S. Thiagarajan, Jacob White, Hanry Yu: The self-limiting dynamics of TGF-signaling in silico and in vitro, with negative feedback through PP1MA upregulation, PLOS Computational Biology, 10(6) (2014)
Sucheendra Kumar Palaniappan, S. Akshay, Bing Liu, B.Genest and P.S. Thiagarajan: A Hybrid Factored Frontier Algorithm for Dynamic Bayesian Networks with a Biopathways Application, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9(5) (2012)
Bing Liu, Andrei Hagiescu, Sucheendra K. Palaniappan, Bipasa Chattopadhyay, Zheng Cui,Weng-FaiWong and P.S. Thiagarajan: Approximate Probabilistic Analysis of Biopathways Dynamics, Bioinformatics, 28(11) (2012)
Bing Liu, Jing Zhang, Pei Yi Tan, David Hsu, Anna M. Blom, Benjamin Leong, Sunil Sethi, Bow Ho, Jeak Leak Ding and P.S. Thiagarajan: A Combined Computational and Experimental Study of the Regulatory Mechanisms of the Complement System, PLoS Computational Biology, 7(1) (2011).