Publications

2017
Sackton, Timothy B, Brian P Lazzaro, and Andrew G Clark. 2017. “Rapid expansion of immune-related gene families in the house fly, Musca domestica.” Molecular biology and evolution 34 (4): 857. Publisher's Version
2016
Rago, Alfredo, Donald G Gilbert, Jeong-Hyeon Choi, Timothy B Sackton, Xu Wang, Yogeshwar D Kelkar, John H Werren, and John K Colbourne. 2016. “OGS2: genome re-annotation of the jewel wasp Nasonia vitripennis.” BMC Genomics 17 (1): 678. Publisher's Version
Sackton, Timothy B., and Daniel L. Hartl. 2016. “Genotypic context and epistasis in individuals and populations.” Cell 166 (2): 279-287. Publisher's Version
2015
Corbett-Detig, Russell B, Daniel L Hartl, and Timothy B Sackton. 2015. “Natural Selection Constrains Neutral Diversity across A Wide Range of Species.” PLOS Biology 13 (4): e1002112. Publisher's Version
2014
Scott, Jeffrey G, Wesley C Warren, Leo W Beukeboom, Daniel Bopp, Andrew G Clark, Sarah D Giers, Monika Hediger, et al. 2014. “Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment.” Genome Biol 15 (10): 466. Abstract
BACKGROUND: Adult house flies, Musca domestica L., are mechanical vectors of more than 100 devastating diseases that have severe consequences for human and animal health. House fly larvae play a vital role as decomposers of animal wastes, and thus live in intimate association with many animal pathogens. RESULTS: We have sequenced and analyzed the genome of the house fly using DNA from female flies. The sequenced genome is 691 Mb. Compared with Drosophila melanogaster, the genome contains a rich resource of shared and novel protein coding genes, a significantly higher amount of repetitive elements, and substantial increases in copy number and diversity of both the recognition and effector components of the immune system, consistent with life in a pathogen-rich environment. There are 146 P450 genes, plus 11 pseudogenes, in M. domestica, representing a significant increase relative to D. melanogaster and suggesting the presence of enhanced detoxification in house flies. Relative to D. melanogaster, M. domestica has also evolved an expanded repertoire of chemoreceptors and odorant binding proteins, many associated with gustation. CONCLUSIONS: This represents the first genome sequence of an insect that lives in intimate association with abundant animal pathogens. The house fly genome provides a rich resource for enabling work on innovative methods of insect control, for understanding the mechanisms of insecticide resistance, genetic adaptation to high pathogen loads, and for exploring the basic biology of this important pest. The genome of this species will also serve as a close out-group to Drosophila in comparative genomic studies.
Sackton, Timothy B, Russell B Corbett-Detig, Javaregowda Nagaraju, Lakshmi Vaishna, Kallare P Arunkumar, and Daniel L Hartl. 2014. “Positve selection drives faster-Z evolution in silkmoths.” Evolution 68: 2331–2342. Publisher's Version
Sackton 2014 Evolution
Adrion, Jeffrey R, Athanasios Kousathanas, Marta Pascual, Hannah J Burrack, Nick M Haddad, Alan O Bergland, Heather Machado, et al. 2014. “Drosophila suzukii: the genetic footprint of a recent, world-wide invasion.” Molecular biology and evolution. Oxford University Press, msu246. Publisher's Version
Sackton, Katharine L, Nevena Dimova, Xing Zeng, Wei Tian, Mengmeng Zhang, Timothy B Sackton, Johnathan Meaders, et al. 2014. “Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.” Nature Epub ahead of print. Nature Publishing Group. Publisher's Version
2013
Sackton, Timothy B, John H Werren, and Andrew G Clark. 2013. “Characterizing the infection-induced transcriptome of Nasonia vitripennis reveals a preponderance of taxonomically-restricted immune genes.” PloS one 8. Public Library of Science: e83984. Publisher's Version
Sackton, Timothy B, and Daniel L Hartl. 2013. “Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.” Genome biology and evolution 5. Oxford University Press: 255–266. Publisher's Version
2012
Whiteman, Noah K, Andrew D Gloss, Timothy B Sackton, Simon C Groen, Parris T Humphrey, Richard T Lapoint, Ida E Sønderby, et al. 2012. “Genes involved in the evolution of herbivory by a leaf-mining, drosophilid fly.” Genome biology and evolution 4. Oxford University Press: 788–804.
Zhou, Jun, Timothy B Sackton, Lene Martinsen, Bernardo Lemos, Thomas H Eickbush, and Daniel L Hartl. 2012. “Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila.” Proceedings of the National Academy of Sciences 109. National Acad Sciences: 9941–9946.
2011
Sackton, Timothy B, Horacio Montenegro, Daniel L Hartl, and Bernardo Lemos. 2011. “Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila.” Proceedings of the National Academy of Sciences 108. National Acad Sciences: 17046–17051.
2010
Werren, John H, Stephen Richards, Christopher A Desjardins, Oliver Niehuis, Jürgen Gadau, John K Colbourne, and others. 2010. “Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.” Science 327. American Association for the Advancement of Science: 343–348.
Sackton, Timothy B, Brian P Lazzaro, and Andrew G Clark. 2010. “Genotype and gene expression associations with immune function in Drosophila.” PLoS genetics 6. Public Library of Science: e1000797.
2009
Singh, Nadia D, Amanda M Larracuente, Timothy B Sackton, and Andrew G Clark. 2009. “Comparative genomics on the Drosophila phylogenetic tree.” Annual review of ecology, evolution, and systematics 40. Annual Reviews: 459–480.
Sackton, Timothy B, and Andrew G Clark. 2009. “Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing.” BMC genomics 10. BioMed Central Ltd: 259.
Sackton, Timothy B, Rob J Kulathinal, Casey M Bergman, Aaron R Quinlan, Erik B Dopman, Mauricio Carneiro, Gabor T Marth, Daniel L Hartl, and Andrew G Clark. 2009. “Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster.” Genome biology and evolution 1. Oxford University Press: 449.
2008
Larracuente, Amanda M, Timothy B Sackton, Anthony J Greenberg, Alex Wong, Nadia D Singh, David Sturgill, Yu Zhang, Brian Oliver, and Andrew G Clark. 2008. “Evolution of protein-coding genes in Drosophila.” Trends in Genetics 24. Elsevier: 114–123. Publisher's Version
2007
Sackton, Timothy B, Brian P Lazzaro, Todd A Schlenke, Jay D Evans, Dan Hultmark, and Andrew G Clark. 2007. “Dynamic evolution of the innate immune system in Drosophila.” Nature genetics 39. Nature Publishing Group: 1461–1468.

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