Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, and Changning Wang. 2019. “
Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET).” Acta Pharmaceutica Sinica B, 9, 6, Pp. 1204-1215.
Publisher's Version Dong Yang, Hao Wang, Shenglin Luo, Changning Wang, Sheng Zhang, and Shiqi Guo. 2019. “
Paper-Cut Flexible Multifunctional Electronics Using MoS2 Nanosheet.” Nanomaterials, 9, 7, Pp. 922.
Publisher's Version Tonya M. Gilbert, Nicole R. Zürcher, Christine J. Wu, Anisha Bhanot, Baileigh G. Hightower, Minhae Kim, Daniel S. Albrecht, Hsiao-Ying Wey, Frederick A. Schroeder, Anais Rodriguez-Thompson, Thomas M. Morin, Kamber L. Hart, Amelia M. Pellegrini, Misha M. Riley, Changning Wang, Steven M. Stufflebeam, Stephen J. Haggarty, Daphne J. Holt, Marco L. Loggia, Roy H. Perlis, Hannah E. Brown, Joshua L. Roffman, and Jacob M. Hooker. 2019. “
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.” The Journal of Clinical Investigation, 129, 1, Pp. 364-372.
Publisher's VersionAbstractBACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. Here we investigated the relationship between in vivo HDAC expression and cognitive impairment in patients with SCZ and matched healthy controls using [11C]Martinostat positron emission tomography (PET). METHODS. In a case-control study, relative [11C]Martinostat uptake was compared between 14 patients with SCZ or schizoaffective disorder (SCZ/SAD) and 17 controls using hypothesis-driven region-of-interest analysis and unbiased whole brain voxel-wise approaches. Clinical measures, including the MATRICS consensus cognitive battery, were administered. RESULTS. Relative HDAC expression was lower in the DLPFC of patients with SCZ/SAD compared with controls, and HDAC expression positively correlated with cognitive performance scores across groups. Patients with SCZ/SAD also showed lower relative HDAC expression in the dorsomedial prefrontal cortex and orbitofrontal gyrus, and higher relative HDAC expression in the cerebral white matter, pons, and cerebellum compared with controls. CONCLUSIONS. These findings provide in vivo evidence of HDAC dysregulation in patients with SCZ and suggest that altered HDAC expression may impact cognitive function in humans. FUNDING. National Institute of Mental Health (NIMH), Brain and Behavior Foundation, Massachusetts General Hospital (MGH), Athinoula A. Martinos Center for Biomedical Imaging, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH Shared Instrumentation Grant Program.
Ping Bai, Hsiao-Ying Wey, Debasis Patnaik, Xiaoxia Lu, Yu Lan, Johanna Rokka, Fiedler Stephanie, Stephen J. Haggarty, and Changning Wang. 2019. “
Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.” Chemical Communications, 55, 86, Pp. 12932-12935.
Publisher's Version Zude Chen, Xiashuang Wang, Yulong Xu, and Changning Wang. 2019. “
Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof.” Nuclear Medicine and Biology, 78-79, Pp. 17-22.
Publisher's Version Michael S. Placzek, Frederick A. Schroeder, Tao Che, Hsiao-Ying Wey, Ramesh Neelamegam, Changning Wang, Bryan L. Roth, and Jacob Hooker. 2019. “
Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging.” ACS Chem. Neurosci., 10, Pp. 1384-395.
Publisher's Version Tonya M. Gilbert, Nicole R. Zürcher, Mary C. Catanese, Chieh-En J. Tseng, Maria A. Di Biase, Amanda E. Lyall, Baileigh G. Hightower, Anjali J. Parmar, Anisha Bhanot, Christine J. Wu, Matthew L. Hibert, Minhae Kim, Umar Mahmood, Steven M. Stufflebeam, Frederick A. Schroeder, Changning Wang, Joshua L. Roffman, Daphne J. Holt, Douglas N. Greve, Ofer Pasternak, Marek Kubicki, Hsiao-Ying Wey, and Jacob M. Hooker. 2019. “
Neuroepigenetic signatures of age and sex in the living human brain.” Nature Communications, 10, 2945.
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