Publications

2020
Yiwei Zhu, Stephanie A. Fiedler, Matthew L. Hibert, and Changning Wang. 2020. “Synthesis of a carbon-11 radiolabeled BACE1 inhibitor.” Medicinal Chemistry Research. Publisher's Version
2019
Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, and Changning Wang. 2019. “Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET).” Acta Pharmaceutica Sinica B, 9, 6, Pp. 1204-1215. Publisher's Version
Dong Yang, Hao Wang, Shenglin Luo, Changning Wang, Sheng Zhang, and Shiqi Guo. 2019. “Paper-Cut Flexible Multifunctional Electronics Using MoS2 Nanosheet.” Nanomaterials, 9, 7, Pp. 922. Publisher's Version
Tonya M. Gilbert, Nicole R. Zürcher, Christine J. Wu, Anisha Bhanot, Baileigh G. Hightower, Minhae Kim, Daniel S. Albrecht, Hsiao-Ying Wey, Frederick A. Schroeder, Anais Rodriguez-Thompson, Thomas M. Morin, Kamber L. Hart, Amelia M. Pellegrini, Misha M. Riley, Changning Wang, Steven M. Stufflebeam, Stephen J. Haggarty, Daphne J. Holt, Marco L. Loggia, Roy H. Perlis, Hannah E. Brown, Joshua L. Roffman, and Jacob M. Hooker. 2019. “PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.” The Journal of Clinical Investigation, 129, 1, Pp. 364-372. Publisher's VersionAbstract
BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. Here we investigated the relationship between in vivo HDAC expression and cognitive impairment in patients with SCZ and matched healthy controls using [11C]Martinostat positron emission tomography (PET). METHODS. In a case-control study, relative [11C]Martinostat uptake was compared between 14 patients with SCZ or schizoaffective disorder (SCZ/SAD) and 17 controls using hypothesis-driven region-of-interest analysis and unbiased whole brain voxel-wise approaches. Clinical measures, including the MATRICS consensus cognitive battery, were administered. RESULTS. Relative HDAC expression was lower in the DLPFC of patients with SCZ/SAD compared with controls, and HDAC expression positively correlated with cognitive performance scores across groups. Patients with SCZ/SAD also showed lower relative HDAC expression in the dorsomedial prefrontal cortex and orbitofrontal gyrus, and higher relative HDAC expression in the cerebral white matter, pons, and cerebellum compared with controls. CONCLUSIONS. These findings provide in vivo evidence of HDAC dysregulation in patients with SCZ and suggest that altered HDAC expression may impact cognitive function in humans. FUNDING. National Institute of Mental Health (NIMH), Brain and Behavior Foundation, Massachusetts General Hospital (MGH), Athinoula A. Martinos Center for Biomedical Imaging, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH Shared Instrumentation Grant Program.
Ping Bai, Hsiao-Ying Wey, Debasis Patnaik, Xiaoxia Lu, Yu Lan, Johanna Rokka, Fiedler Stephanie, Stephen J. Haggarty, and Changning Wang. 2019. “Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.” Chemical Communications, 55, 86, Pp. 12932-12935. Publisher's Version
Zude Chen, Xiashuang Wang, Yulong Xu, and Changning Wang. 2019. “Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof.” Nuclear Medicine and Biology, 78-79, Pp. 17-22. Publisher's Version
Michael S. Placzek, Frederick A. Schroeder, Tao Che, Hsiao-Ying Wey, Ramesh Neelamegam, Changning Wang, Bryan L. Roth, and Jacob Hooker. 2019. “Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging.” ACS Chem. Neurosci., 10, Pp. 1384-395. Publisher's Version
Tonya M. Gilbert, Nicole R. Zürcher, Mary C. Catanese, Chieh-En J. Tseng, Maria A. Di Biase, Amanda E. Lyall, Baileigh G. Hightower, Anjali J. Parmar, Anisha Bhanot, Christine J. Wu, Matthew L. Hibert, Minhae Kim, Umar Mahmood, Steven M. Stufflebeam, Frederick A. Schroeder, Changning Wang, Joshua L. Roffman, Daphne J. Holt, Douglas N. Greve, Ofer Pasternak, Marek Kubicki, Hsiao-Ying Wey, and Jacob M. Hooker. 2019. “Neuroepigenetic signatures of age and sex in the living human brain.” Nature Communications, 10, 2945. Publisher's Version
2018
Genevieve C. Van de Bittner, Misha M. Riley, Luxiang Cao, Janina Ehses, Scott P. Herrick, Emily L. Ricq, Hsiao-Ying Wey, Michael J. O’Neill, Zeshan Ahmed, Tracey K. Murray, Jaclyn E. Smith, Changning Wang, Frederick A. Schroeder, Mark W. Albers, and Jacob M. Hooker. 2018. “Nasal neuron PET imaging quantifies neuron generation and degeneration.” Jacob M. Hooker, 127, 2, Pp. 681-694. Publisher's Version
2017
Changning Wang*, Frederick A. Schroeder, and Jacob M. Hooker. 1/2017. “Development of New Positron Emission Tomography Radiotracer for BET Imaging.” ACS Chem. Neurosci., 8, 1, Pp. 17-21. Publisher's Version
2016
Martin G. Strebl, Changning Wang, Frederick A. Schroeder, Michael S. Placzek, Hsiao-Ying Wey, Genevieve C. Van de Bittner, Ramesh Neelamegam, and Jacob M. Hooker*. 2016. “Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. .” ACS Chem Neurosci. , 7, 5, Pp. 528–533. Publisher's Version
Benjamin H. Rotstein, Michael S. Placzek, Hema S. Krishnan, Aleksandra Pekosak, Thomas Lee Collier, Changning Wang, Steven H. Liang, Ethan S. Burstein, Jacob M. Hooker, and Neil Vasdev*. 2016. “Preclinical PET neuroimaging of [11C]bexarotene. .” Molecular Imaging., 15, Pp. 1-5. Publisher's Version
Hsiao-Ying Wey, Tonya M. Gilbert, Nicole R. Zürcher, Angela She, Anisha Bhanot, Brendan D. Taillon, Fredrick A. Schroeder, Changning Wang, Stephen J. Haggarty, and Jacob M. Hooker*. 2016. “Insights into neuroepigenetics through human histone deacetylase PET imaging.” Science Translational Medicine. , 8, 351, Pp. 351ra106. Publisher's Version
2015
Changning Wang*, Michael S. Placzek, Genevieve C. Van de Bittner, Frederick A. Schroeder, and Jacob M. Hooker. 12/22/2015. “A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography.” ACS Chem. Neurosci., 7, 4, Pp. 484-489. Publisher's Version
Hsiao-Ying Wey*, Changning Wang, Frederick A. Schroeder, Jean Logan, Julie C. Price, and Jacob M. Hooker*. 2015. “Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain. .” ACS Chem Neurosci. , 6, 5, Pp. 708–715. Publisher's Version
2014
Changning Wang, Thomas E Eessalu, Vanessa N Barth, Charles H Mitch, Florence F Wagner, Yijia Hong, Ramesh Neelamegam, Frederick A Schroeder, Edward B Holson, Stephen J Haggarty, and Jacob M Hooker*. 2014. “Design, Synthesis, and Evaluation of Hydroxamic Acid-Based Molecular Probes for Imaging of Histone Deacetylase (HDAC). .” Am J Nucl Med Mol Imaging. , 4, 1, Pp. 29–38. Publisher's Version
Ramesh Neelamegam, Tim Hellenbrand, Frederick A. Schroeder, Changning Wang, and Jacob M. Hooker*. 2014. “Imaging evaluation of 5-HT2C agonists, [11C]WAY-163909 and [11C]vabicaserin, formed by Pictet-Spengler cyclization. .” J Med Chem. , 57, 4, Pp. 1488–1494. Publisher's Version
Changning Wang, Frederick A. Schroeder, Hsiao-Ying Wey, Ronald Borra, Florence F. Wagner, Surya Reis, Sungwon Kim, Edward B. Holson, Stephen J. Haggarty, and Jacob M. Hooker*. 2014. “In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs. .” J Med Chem. , 57, 19, Pp. 7999–8009. Publisher's Version
F. A. Schroeder, C. Wang, G. C. Van de Bittner, R. Neelamegam, W. R. Takakura, A. Karunakaran, H. Y. Wey, S. A. Reis, J. Gale, Y. L. Zhang, E. B. Holson, S. J. Haggarty, and J. M. Hooker*. 2014. “PET imaging demonstrates HDAC target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. .” ACS Chem Neurosci. , 5, 10, Pp. 1055–1062. Publisher's Version
C. Wang, F. A. Schroeder, and J. M. Hooker*. 2014. “Visualizing epigenetics: Current advances and advantages in HDAC PET imaging techniques. .” Neuroscience. , 264, Pp. 186–197. Publisher's Version

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