Zhipei Sang, Keren Wang, Ping Bai, Anguo Wu, Jian Shi, Wenmin Liu, Gaofeng Zhu, Yiling Wang, Yu Lan, Zude Chen, Yiyang Zhao, Zhanpin Qiao, Changning Wang, and Zhenghuai Tan. 5/2020. “Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer’s disease.” European Journal of Medicinal Chemistry, 194, Pp. 112265. Publisher's Version
Ping Bai, Xiaoxia Lu, Yu Lan, Zude Chen, Debasis Patnaik, Stephanie Fiedler, Robin Striar, Stephen J. Haggarty, and Changning Wang. 4/2020. “Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins.” Nuclear Medicine and Biology, 84-85, Pp. 96-101. Publisher's Version
Ping Bai, Sha Bai, Michael S. Placzek, Xiaoxia Lu, Stephanie Fiedler, Brenda Ntaganda, Hsiao-Ying Wey, and Changning Wang. 3/2020. “A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging.” Molecules, 25, 5, Pp. 1018. Publisher's Version
Yiwei Zhu, Stephanie A. Fiedler, Matthew L. Hibert, and Changning Wang. 1/2020. “Synthesis of a carbon-11 radiolabeled BACE1 inhibitor.” Medicinal Chemistry Research. Publisher's Version
Ping Bai, Yu Lan, Hao Wang, Zude Chen, Stephanie Fiedler, Robin Striar, Xiaoxia Lu, and Changning Wang. 2020. “Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins.” Front. Mol. Biosci. . Publisher's Version
Zude Chen, Xiashuang Wang, Xiaoshuang Yang, Yulong Xu, Yu Yang, Hao Wang, Tao Li, Ping Bai, Gengyang Yuan, Huabiao Chen, Jing Yang, Stephanie A. Fiedler, Robin Striar, Daniela R. Bernales, Robert E. Koegel, Qi Cao, Chongzhao Ran, Bo Xiang, Hong Li, and Changning Wang. 2020. “Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer.” European Journal of Nuclear Medicine and Molecular Imaging. Publisher's Version
Chieh-En J. Tseng, Tonya M. Gilbert, Mary C. Catanese, Baileigh G. Hightower, Amy T. Peters, Anjali J. Parmar, Minhae Kim, Changning Wang, Joshua L. Roffman, Hannah E. Brown, Roy H. Perlis, Nicole R. Zürcher, and Jacob M. Hooker. 2020. “In vivo human brain expression of histone deacetylases in bipolar disorder.” Transl Psychiatry. Publisher's Version
Yulong Xu, Changning Wang, Hsiao-Ying Wey, Yingxia Liang, Zude Chen, Se Hoon Choi, Chongzhao Ran, Kevin D. Rynearson, Daniela R. Bernales, Robert E. Koegel, Stephanie A. Fiedler, Robin Striar, Steven L. Wagner, Rudolph Tanzi, and Can Zhang. 2020. “Molecular imaging of Alzheimer’s disease-related gamma-secretase.” Journal of Experimental Medicine.
Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, and Changning Wang. 2019. “Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET).” Acta Pharmaceutica Sinica B, 9, 6, Pp. 1204-1215. Publisher's Version
Dong Yang, Hao Wang, Shenglin Luo, Changning Wang, Sheng Zhang, and Shiqi Guo. 2019. “Paper-Cut Flexible Multifunctional Electronics Using MoS2 Nanosheet.” Nanomaterials, 9, 7, Pp. 922. Publisher's Version
Tonya M. Gilbert, Nicole R. Zürcher, Christine J. Wu, Anisha Bhanot, Baileigh G. Hightower, Minhae Kim, Daniel S. Albrecht, Hsiao-Ying Wey, Frederick A. Schroeder, Anais Rodriguez-Thompson, Thomas M. Morin, Kamber L. Hart, Amelia M. Pellegrini, Misha M. Riley, Changning Wang, Steven M. Stufflebeam, Stephen J. Haggarty, Daphne J. Holt, Marco L. Loggia, Roy H. Perlis, Hannah E. Brown, Joshua L. Roffman, and Jacob M. Hooker. 2019. “PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.” The Journal of Clinical Investigation, 129, 1, Pp. 364-372. Publisher's VersionAbstract
BACKGROUND. Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. Here we investigated the relationship between in vivo HDAC expression and cognitive impairment in patients with SCZ and matched healthy controls using [11C]Martinostat positron emission tomography (PET). METHODS. In a case-control study, relative [11C]Martinostat uptake was compared between 14 patients with SCZ or schizoaffective disorder (SCZ/SAD) and 17 controls using hypothesis-driven region-of-interest analysis and unbiased whole brain voxel-wise approaches. Clinical measures, including the MATRICS consensus cognitive battery, were administered. RESULTS. Relative HDAC expression was lower in the DLPFC of patients with SCZ/SAD compared with controls, and HDAC expression positively correlated with cognitive performance scores across groups. Patients with SCZ/SAD also showed lower relative HDAC expression in the dorsomedial prefrontal cortex and orbitofrontal gyrus, and higher relative HDAC expression in the cerebral white matter, pons, and cerebellum compared with controls. CONCLUSIONS. These findings provide in vivo evidence of HDAC dysregulation in patients with SCZ and suggest that altered HDAC expression may impact cognitive function in humans. FUNDING. National Institute of Mental Health (NIMH), Brain and Behavior Foundation, Massachusetts General Hospital (MGH), Athinoula A. Martinos Center for Biomedical Imaging, National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH Shared Instrumentation Grant Program.
Ping Bai, Hsiao-Ying Wey, Debasis Patnaik, Xiaoxia Lu, Yu Lan, Johanna Rokka, Fiedler Stephanie, Stephen J. Haggarty, and Changning Wang. 2019. “Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.” Chemical Communications, 55, 86, Pp. 12932-12935. Publisher's Version
Zude Chen, Xiashuang Wang, Yulong Xu, and Changning Wang. 2019. “Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof.” Nuclear Medicine and Biology, 78-79, Pp. 17-22. Publisher's Version
Michael S. Placzek, Frederick A. Schroeder, Tao Che, Hsiao-Ying Wey, Ramesh Neelamegam, Changning Wang, Bryan L. Roth, and Jacob Hooker. 2019. “Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging.” ACS Chem. Neurosci., 10, Pp. 1384-395. Publisher's Version
Tonya M. Gilbert, Nicole R. Zürcher, Mary C. Catanese, Chieh-En J. Tseng, Maria A. Di Biase, Amanda E. Lyall, Baileigh G. Hightower, Anjali J. Parmar, Anisha Bhanot, Christine J. Wu, Matthew L. Hibert, Minhae Kim, Umar Mahmood, Steven M. Stufflebeam, Frederick A. Schroeder, Changning Wang, Joshua L. Roffman, Daphne J. Holt, Douglas N. Greve, Ofer Pasternak, Marek Kubicki, Hsiao-Ying Wey, and Jacob M. Hooker. 2019. “Neuroepigenetic signatures of age and sex in the living human brain.” Nature Communications, 10, 2945. Publisher's Version
Genevieve C. Van de Bittner, Misha M. Riley, Luxiang Cao, Janina Ehses, Scott P. Herrick, Emily L. Ricq, Hsiao-Ying Wey, Michael J. O’Neill, Zeshan Ahmed, Tracey K. Murray, Jaclyn E. Smith, Changning Wang, Frederick A. Schroeder, Mark W. Albers, and Jacob M. Hooker. 2018. “Nasal neuron PET imaging quantifies neuron generation and degeneration.” The Journal of Clinical Investigation, 127, 2, Pp. 681-694. Publisher's Version
Changning Wang*, Frederick A. Schroeder, and Jacob M. Hooker. 1/2017. “Development of New Positron Emission Tomography Radiotracer for BET Imaging.” ACS Chem. Neurosci., 8, 1, Pp. 17-21. Publisher's Version
Martin G. Strebl, Changning Wang, Frederick A. Schroeder, Michael S. Placzek, Hsiao-Ying Wey, Genevieve C. Van de Bittner, Ramesh Neelamegam, and Jacob M. Hooker*. 2016. “Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. .” ACS Chem Neurosci. , 7, 5, Pp. 528–533. Publisher's Version
Benjamin H. Rotstein, Michael S. Placzek, Hema S. Krishnan, Aleksandra Pekosak, Thomas Lee Collier, Changning Wang, Steven H. Liang, Ethan S. Burstein, Jacob M. Hooker, and Neil Vasdev*. 2016. “Preclinical PET neuroimaging of [11C]bexarotene. .” Molecular Imaging., 15, Pp. 1-5. Publisher's Version
Hsiao-Ying Wey, Tonya M. Gilbert, Nicole R. Zürcher, Angela She, Anisha Bhanot, Brendan D. Taillon, Fredrick A. Schroeder, Changning Wang, Stephen J. Haggarty, and Jacob M. Hooker*. 2016. “Insights into neuroepigenetics through human histone deacetylase PET imaging.” Science Translational Medicine. , 8, 351, Pp. 351ra106. Publisher's Version