People-centered health care systems aim to empower people with their health care decisions, make information more accessible, and enable more autonomy. The goal is to promote well-being as much as to treat disease, and to create more collaboration between providers, patients, and their families, thus reducing costs and improving health outcomes. Throughout the world growing populations and rising costs are challenging health care systems. In numerous countries, health care providers are unable to meet the needs of many individuals and groups due to limited budgets, time, and staff. An aging population and rapidly increasing rates of chronic diseases could overwhelm most health care systems. While information and communication technologies can connect health care providers with each other and the consumers they serve, there is no group, organization, or government that has successfully overcome the roadblocks to implementing a wide people-centered health system. Ideally, such a system would put the needs of the public first, enable individuals to take greater responsibility for managing their own health and health services, and promote optimal levels of health and resource utilization. In this paper, we explore a vision for future people-centered health care systems that could provide better access to information and decision-making tools for patients, health care providers, and the general public. We also examine key challenges to creating such systems.